与达比加特兰相关的严重药物错误:使用VigiBase数据进行分析
Qingxia Zhang1, Qian Ding2, Qun-Ying Yue3
1Department of Pharmacy, National Clinical Research Center for Geriatric Disease, Xuanwu Hospital Capital Medical University, Beijing, China. WL7322681@sina.com.
European journal of clinical pharmacology
|January 28, 2024
概括
严重的药物错误 (ME) 与达比加特兰经常发生在处方和管理期间,导致不良事件,如出血和缺血. 谨慎的剂量,患者的遵守和适当的储存对于防止伤害至关重要.
科学领域:
- 药物监督 药物监督 药物监督
- 药品安全 药品安全
- 临床药房 临床药房
背景情况:
- 达比加特兰是一种抗凝剂,用于预防中风和血栓.
- 药物错误 (ME) 可以导致严重的不良事件.
- 分析ME对于提高患者安全至关重要.
研究的目的:
- 分析与达比加特兰相关的严重药物错误.
- 确定导致这些中小企业的因素.
- 为预防不良事件提供见解.
主要方法:
- 涉及达比加特兰的严重ME从世卫组织的VigiBase中提取出来.
- 分析包括了经过充分记录的报告,vigiGrade分数≥0.80.
- 使用了与毒品有关的问题的PCNE分类 (DRP).
主要成果:
- 分析了113起经过充分记录的严重ME,其中61%导致住院,11%导致死亡.
- 处方错误 (77例) 包括药物选择 (禁忌,相互作用) 和剂量问题.
- 管理错误 (35例) 涉及医务人员和患者相关问题,主要不良事件是出血和缺血.
结论:
- 严重的ME与达比加特兰主要发生在处方和管理期间.
- 确保对正确的患者进行正确的剂量选择至关重要.
- 在服用药物时,患者的坚持和适当的药物储存至关重要,以最大限度地减少危害.
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