在绝经后的妇女中,全基因组多基因风险评分对类风湿性关节炎的预测
1Nevada Institute of Personalized Medicine, College of Science, University of Nevada, Las Vegas, NV, USA.
The journal of gene medicine
|January 28, 2024
概括
一个新的多基因风险评分 (PRS) 可以预测绝经后妇女的类风湿关节炎 (RA) 风险. 高PRS与RA患病率增加有关,有助于早期查和个性化医疗方法.
科学领域:
- 遗传学 遗传学 是一个
- 类风湿病学 类风湿病学
- 流行病学 流行病学
背景情况:
- 类风湿性关节炎 (RA) 有着重要的遗传基础.
- 来自全基因组关联研究 (GWAS) 的多基因风险评分 (PRS) 可以预测疾病易感性.
研究的目的:
- 开发和验证用于预测RA风险的PRS.
- 评估PRS在绝经后妇女中的实用性.
主要方法:
- 从GWAS数据中使用225,000个遗传变异开发出了一种新的PRS.
- 在独立的绝经后妇女队伍中验证了PRS (n=8967发展,n=6269验证).
- 队列包括各种祖先 (西班牙裔,非裔美国人,高加索人).
主要成果:
- 高PRS与老年人 (60-70岁和≥70岁) 和超重/肥胖个体的RA风险增加有很强的相关性.
- 在65岁时,最低PRS五分位数的绝对RA风险为30.6%,最高PRS五分位数为53.8%.
- 在PRS五分位数中观察到RA流行率和赔率比率的明显梯度.
结论:
- 发育的PRS与绝经后妇女的RA风险有显著的关联.
- 这个PRS显示了早期RA查和个性化医疗的潜力.
- 需要进一步的研究来评估PRS在不同人群中的实用性.
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