摄入胰岛素的食补充剂通过调节肠道微生物群疾病来改善烧伤引起的骨肌肉缩
Shan Gao1, Xiaoshuai Zhao1, Yan Leng1
1Department of Anaesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Scientific reports
|January 28, 2024
概括
胰岛素补充剂通过调节肠道微生物群和激活PI3K/AKT信号,改善了大鼠的烧伤引起的肌肉缩. 这种前生物干预减少了骨肌肉细胞的亡,并恢复了微生物的平衡.
科学领域:
- 微生物学 微生物学
- 生理学 生理学 生理学
- 营养科学 营养科学
背景情况:
- 烧伤伤害导致肠道失调和骨肌肉的代谢.
- 像胰岛素这样的益生菌在缓解烧伤引起的肌肉缩中的作用尚不清楚.
- 肠道微生物群的改变与燃烧后的代谢功能障碍有关.
研究的目的:
- 为了研究胰岛素摄入是否减轻肠道微生物群疾病和骨肌缩在烧伤的老鼠.
- 阐明潜在的机制,包括微生物和分子途径.
- 评估胰岛素对骨肌肉质量,细胞亡和相关信号通路的影响.
主要方法:
- 烧伤的老鼠模型与假冒,烧伤,胰岛素干预和伪无菌验证组.
- 给干预组注射胰岛素 (7 g/L) 的干预组.
- 分析肠道微生物群的组成,骨肌肉质量,亡以及PI3K/AKT信号通路的激活.
主要成果:
- 胰岛素显著缓解燃烧引起的骨肌肉质量减少和肌细胞亡.
- 胰岛素调节肠道微生物群,增加Firmicutes和Actinobacteria,同时减少蛋白质细菌.
- 胰岛素促进PI3K/AKT信号通路的激活,增强蛋白质合成和氨基酸生物合成.
结论:
- 胰岛素摄入改善了大鼠在烧伤后的骨肌肉缩.
- 胰岛素通过调节肠道微生物群失调和激活PI3K/AKT信号通路来发挥其保护作用.
- 胰岛素代表了一种潜在的治疗策略,用于管理燃烧引起的肌肉损耗.
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
334
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
334
Bacterial Flora of the Large Intestine
451
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
451
Inflammatory Bowel Disease V: Surgical Management
147
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
147
Drugs for Treatment of Constipation-Predominant IBS
169
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
169


