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人类生殖过程和疾病中的长非编码RNA

Le Zhang¹, Hailong Sun¹, Xiujuan Chen¹

¹Center for Reproductive Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.

Molecular reproduction and development

|January 29, 2024

概括

长非编码RNAs (lncRNAs) 在人类繁殖中起着至关重要的作用,影响生育能力. 了解lncRNA机制为治疗不孕症和提高出生率提供了新的策略.

科学领域:

生殖生物学生殖生物学
分子遗传学分子遗传学
基因组学就是基因组学.

背景情况:

不孕症影响着全球大量人口,辅助生殖出生率低于30%.
目前对生殖机制的理解不足以优化活产率和植入成功.
长非编码RNAs (lncRNAs) 越来越多地被认为是它们在各种生物过程中的调节作用.

研究的目的:

审查 lncRNAs 在人类主要生殖过程中的功能和机制.
突出 lncRNAs 作为不孕症诊断生物标志物的潜力.
探索 lncRNAs 作为改善不孕症治疗结果的治疗点.

主要方法:

文献综述侧重于人类生殖中的lncRNAs.
综合目前关于 lncRNA 功能在精子生成, oogenesis 和早期胚胎发育中的研究.
对研究 lncRNA 在精子和卵泡成熟,胚胎植入和整体生殖成功中的作用的分析.

主要成果:

lncRNAs参与调节精子生成,精子质量和卵泡发育.
lncRNAs影响胚胎发育和植入过程.
特定的 lncRNAs 显示出作为诊断不孕症的分子指标的潜力.

结论:

lncRNAs是人类生殖功能的关键调节者.
lncRNAs代表了各种不孕症的有前途的诊断生物标志物.
向lncRNAs为增强生育能力和改善辅助生殖结果提供了一个新的治疗途径.

关键词:

人类繁殖人类的繁殖.长非编码RNAs的编码.潜在的生物标志物潜在的治疗目标.生殖疾病生殖疾病.

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