神经性厌食症和心血管疾病事件之间的共同遗传风险:来自全基因组关联研究的证据
Baiyu Qi1, Mariaelisa Graff1, Eating Disorders Working Group Of The Psychiatric Genomics Consortium
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, US.
Brain and behavior
|January 29, 2024
概括
神经性厌食症 (AN) 的心血管并发症可能不是来自心血管疾病 (CVD) 的共同遗传. 这项研究没有发现一致的遗传联系,这表明AN中的心血管疾病风险可能是疾病的后果.
科学领域:
- 遗传学 遗传学 是一个
- 心血管医学 心血管医学
- 精神病学是一个精神病学.
背景情况:
- 神经性厌食症 (AN) 与严重的心血管并发症有关,影响高达80%的患者.
- 驱动这种心血管风险升高的潜在机制尚不完全理解.
研究的目的:
- 研究神经性厌食症 (AN) 和各种心血管疾病 (CVD) 事件之间的遗传相关性 (rg).
- 为了确定共享的遗传因素是否有助于在AN患者中观察到的心血管风险增加.
主要方法:
- 利用了全基因组关联研究的总结统计数据,用于AN (N=72,517) 和六个心血管疾病事件 (N=390,142到977,323).
- 使用链接不平衡得分回归计算的遗传相关性 (rg).
- 应用于多次测试的错误发现率纠正.
主要成果:
- 在AN和心力衰竭 (rg = -0.11,q = 0.04) 和心肌梗塞 (rg = -0.10,q = 0.01) 之间发现了显著的负遗传相关性.
- 过度饮食的AN显示与心肌梗塞有显著的负遗传相关性 (rg = -0.15,q = 0.02).
- 在没有暴饮暴食的AN与任何心血管疾病事件之间没有观察到显著的遗传相关性.
结论:
- 在AN和CVD事件之间共享的遗传效应并非始终被观察到,并且可以在相反的方向上起作用.
- 这些发现表明,AN中心血管风险升高不太可能是由于共同的遗传基础.
- 在AN中,心血管并发症更可能是疾病本身的下游后果.
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