在免疫检查点抑制剂治疗期间因感染而入院的病例 没有免疫抑制剂的治疗
Ye Sul Jeung1, June Young Chun1, Beom Kyu Choi2
1Department of Internal Medicine, National Cancer Center, Goyang, Republic of Korea.
Journal of immunotherapy (Hagerstown, Md. : 1997)
|January 29, 2024
概括
在接受免疫检查点抑制剂 (ICI) 治疗肺癌的患者中,即使没有免疫抑制剂,也可能发生初级感染. 早期临床意识对于迅速诊断和管理这些罕见事件至关重要.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 免疫抑制剂常用于控制与免疫相关的不良影响,导致二次感染的增加.
- 在没有免疫抑制剂的免疫检查点抑制剂 (ICI) 治疗期间,原发性感染的发生率和特征在很大程度上是未知的.
研究的目的:
- 评估先进非小细胞肺癌患者中原发性传染病的发病率和临床特征,这些患者在没有同时接受免疫抑制治疗的情况下接受了抗编程死亡-1免疫疗法.
主要方法:
- 对233名接受ICI治疗的患者的医疗记录进行了回顾性查.
- 对80名因潜在感染而入院但没有免疫抑制的患者的临床特征和结果的评估.
- 鉴定致病原体和分析相对于ICI启动的感染时间.
主要成果:
- 初级细菌感染 (肺炎,细胞炎等) 的发病率低 (3.4%). 在不服用免疫抑制剂的患者中观察到.
- 在肺炎病例中发现了肺炎链球菌和Hemophilus influenzae.
- 大多数感染发生在ICI开始后的一个月内;所有患者都没有并发症而康复.
结论:
- 独立于免疫抑制的传染病很少见,但在接受ICI治疗的肺癌患者中可能发生.
- 需要提高临床意识,以便在免疫治疗期间及时诊断原发性感染.
- 感染后,一些患者经历了ICI相关的不良反应,如疹和肺炎.
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