怀孕期间的营养:对肠道微生物群和胎儿发育的影响
Gabriela Barrientos1,2, Francesca Ronchi3, Melanie L Conrad3
1Laboratory of Experimental Medicine, Hospital Alemán, Buenos Aires, Argentina.
American journal of reproductive immunology (New York, N.Y. : 1989)
|January 29, 2024
概括
怀孕期间母亲的营养和肠道微生物组的变化会影响胎儿的发育和长期后代的健康. 这些因素通过代谢物影响胎儿编程,影响产后适应和以后的生活健康结果.
科学领域:
- 生殖生物学 生殖生物学
- 微生物学 微生物学
- 代谢科学 代谢科学
背景情况:
- 母亲的健康和饮食极大地影响胎儿的发育.
- 在怀孕期间,母亲的肠道微生物组经历了显著的重塑.
- 由母体肠道产生的代谢物可以穿过胎盘,影响胎儿的生长.
研究的目的:
- 审查怀孕和母亲的饮食如何改变母亲的肠道微生物群和代谢物生产.
- 评估这些修改对胎儿发育和后代健康的影响.
- 探索母亲因素与健康和疾病发育起源 (DOHaD) 假设之间的联系.
主要方法:
- 关于母亲微生物组,新陈代谢和胎儿发育研究的文献综述.
- 分析母亲的饮食摄入量如何影响肠道微生物群的组成和功能.
- 检查通过胎盘的代谢物转移及其对胎儿编程的影响.
主要成果:
- 怀孕和饮食显著改变母亲的肠道微生物群和代谢物概况.
- 孕产妇的代谢物,包括短链脂肪酸,影响胎儿器官系统的发育.
- 在敏感的妊娠期中,母亲的环境发生变化,可能会导致持久的DOHaD效应.
结论:
- 母亲的肠道微生物组和代谢状态是胎儿发育和后代健康的关键决定因素.
- 怀孕期间的饮食干预可以调节母亲的微生物组,以改善胎儿的编程.
- 了解这些相互作用对于预防后代长期健康问题至关重要.
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