揭露隐藏的负担:估计2型糖尿病老年人全因死亡风险
Dikang Pan1, Hui Wang1, Sensen Wu1
1Xuanwu Hospital, Capital Medical University, Beijing, China.
Journal of diabetes research
|January 29, 2024
概括
一个新的名图准确地预测了2型糖尿病 (T2D) 的老年人5年死亡风险. 这种工具使用年龄,性别,功能和白细胞计数,有助于针对这个日益严重的健康问题进行个性化干预.
科学领域:
- 老年学是一门学科.
- 内分泌学 在内分泌学.
- 生物统计学 生物统计学
背景情况:
- 糖尿病老年人死亡率的上升带来了重大的健康和经济挑战.
- 2型糖尿病 (T2D) 影响着老年人口的很大一部分.
- 准确的风险预测对于老年人T2D的管理至关重要.
研究的目的:
- 开发和验证T2D老年人5年全因死亡风险的预测性名录.
- 确定这一人口群体中死亡率的关键预测因素.
- 为个性化风险评估和干预提供一个工具.
主要方法:
- 利用了来自国家健康和营养调查 (NHANES) 的数据.
- 在培训队列上使用后勤回归和LASSO回归用于名ogram开发.
- 通过使用单独的验证队列与7:3分割和死亡率数据到2019年12月验证了名录.
主要成果:
- 构建了一个预测模型,包括年龄,性别,估计的膜过率和白细胞计数.
- 诺米图实现了0.748 (培训) 和0.762 (验证) 的C指数值.
- 校准曲线证实了培训和验证队伍之间令人满意的一致性.
结论:
- 开发的诺米图是预测T2D老年人5年全因死亡率的有效工具.
- 它为定制医疗干预提供了宝贵的见解.
- 该模型展示了良好的预测性能和校准.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.4K
Actuarial Approach
79
The actuarial approach, a statistical method originally developed for life insurance risk assessment, is widely used to calculate survival rates in clinical and population studies. This method accounts for participants lost to follow-up or those who die from causes unrelated to the study, ensuring a more accurate representation of survival probabilities.
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
79
Diabetes: Symptoms, Diagnosis, and Complications
544
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
544
Carbohydrate Metabolism
11.1K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.1K
Psychoneuroimmunology: Diabetes and Cancer
29
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
29
Diabetes Mellitus: Overview and Type I Subtype
2.6K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.6K


