Jove
Visualize
联系我们

相关概念视频

Autoimmune Disorders01:29

Autoimmune Disorders

439
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
439
Tumor Immunotherapy01:27

Tumor Immunotherapy

526
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
526
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.6K
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

137
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
137
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

68.3K
Overview
68.3K
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

166
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
166

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Exploring the Vasculitis-Tumors Link: Epidemiological Patterns, Mechanistic Insights, and Clinical Implications.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Fibroblast Yap/Taz Signaling in Extracellular Matrix Homeostasis and Tissue Fibrosis.

Journal of clinical medicine·2024
Same author

Advances and challenges in management of large vessel vasculitis.

Rheumatology and immunology research·2023
Same author

mRNA vaccine against fibroblast activation protein ameliorates murine models of inflammatory arthritis.

Rheumatology and immunology research·2023
Same author

Schnitzler syndrome-An underdiagnosed adult-onset autoinflammatory disease.

International journal of rheumatic diseases·2023
Same author

The bacterial link with rheumatoid arthritis.

International journal of rheumatic diseases·2023
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Jul 4, 2025

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
07:25

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis

Published on: May 4, 2017

17.8K

针对自身免疫性疾病的补充向治疗.

Cong-Qiu Chu1,2

  • 1Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR, USA.

Medical review (2021)
|January 29, 2024
PubMed
概括

针对性疗法正在通过抑制补充活性来治疗自身免疫性疾病. 小干扰RNA (siRNA) 是有前途的,可能与自身抗体减少相结合,可有效治疗.

科学领域:

  • 免疫学 免疫学 免疫学
  • 药理学 药理学是指药理学的学科.
  • 治疗方法 治疗方法

背景情况:

  • 补充介导血解治疗显示出成功,推动了向治疗的发展.
  • 疗法正在从罕见的自身免疫性疾病扩展到更常见的疾病.
  • 各种药物类别 (小分子,,单克隆抗体,siRNA) 准补充活性.

研究的目的:

  • 探索针对自身免疫性疾病的向治疗方法的开发.
  • 评估小干扰RNA (siRNA) 作为治疗工具的潜力.
  • 研究复杂的自身免疫性疾病的组合策略.

主要方法:

  • 审查目前用于补充向治疗的药物开发.
  • 对抑制补充产生的小干扰RNA (siRNA) 机制的分析.
  • 探索双模式治疗方法.

主要成果:

  • 针对补充介导疾病的向疗法是成功和安全的.
  • siRNA正在成为抑制补充的强有力的治疗剂.
  • 组合疗法 (siRNA加自抗体降低) 在临床上是可行的.

结论:

关键词:
自身免疫性疾病 自身免疫性疾病补充补充补充补充补充补充补充.这是一个双重目标.siRNA 是一个RNA.

更多相关视频

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
11:31

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

Published on: August 16, 2019

7.9K
Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

30.6K

相关实验视频

Last Updated: Jul 4, 2025

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
07:25

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis

Published on: May 4, 2017

17.8K
High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
11:31

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

Published on: August 16, 2019

7.9K
Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

30.6K
  • 针对性疗法正在扩大自身免疫性疾病,利用补充抑制.
  • siRNA提供了一种有前途的方法来抑制补充剂的产生.
  • 结合的siRNA和自身抗体降低策略可能会显著影响自身免疫性疾病的管理.