脂质参数与儿童过敏鼻炎的过程之间的关系
Agnieszka Kowalczyk1, Aneta Krogulska1
1Department of Paediatrics, Allergology and Gastroenterology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
Postepy dermatologii i alergologii
|January 29, 2024
概括
患有过敏性鼻炎 (AR) 的儿童表现出与一般人群相似的脂质失调率. 然而,脂质异常可能会增加对常见过敏原 (如灰尘和狗皮) 的敏感性.
科学领域:
- 儿科过敏和免疫学
- 临床脂质学 临床脂质学
- 免疫学 免疫学 免疫学
背景情况:
- 高胆固醇血症是过敏性鼻炎 (AR) 发病的一个潜在因素,可能会使免疫反应向Th2.2倾斜.
- 了解AR儿童的脂质代谢对于管理这种情况至关重要.
研究的目的:
- 为了确定患有AR的儿童脂质代谢异常的患病率.
- 研究这些脂质异常对儿科AR的临床表现和过敏原敏感化模式的影响.
主要方法:
- 该研究包括80名AR儿童 (7-17岁) 和40名健康对照.
- 评估脂质特征 (总胆固醇,高血压胆固醇,低血压胆固醇,甘油三),进行皮肤刺痛测试,甲胆挑战测试,并测量过敏原特定的IgE,FeNO和nNO.
主要成果:
- 与对照组相比,AR儿童的正常HDL水平明显高于正常HDL水平 (87.5%vs67.5%).
- 较高的总胆固醇与对*D. pteronyssinus* (72%) 的敏感性增加相关.
- 正常的总胆固醇和甘油三与对狗皮的敏感性降低有关 (78.18%和72.41%).
结论:
- 儿科AR患者表现出与一般人群相比的失脂症患病率.
- 患有AR的儿童的特定脂质异常可能会增加对永久性过敏原敏感化的风险.
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