相关实验视频

Updated: Jul 4, 2025

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

Published on: May 27, 2021

对于组合药物疗法进行端到端的nary关系提取

Yuhang Jiang¹, Ramakanth Kavuluru²

¹Department of Computer Science, University of Kentucky, Lexington, KY USA.

Proceedings. IEEE International Conference on Healthcare Informatics

|January 29, 2024

概括

从科学文献中提取组合药物疗法是一个动态的n-ary关系提取挑战. 一个新的序列对序列模型在CombDrugExt数据集上实现了最新的66.7%的F1分数.

科学领域:

生物医学信息学生物医学信息学
自然语言处理自然语言处理.
计算机化药物发现技术

背景情况:

组合药物治疗对于治疗复杂疾病,如癌症,艾滋病毒,疟疾和结核病至关重要.
从科学文献中提取这些疗法是一个与动态'n' (药物数量) 的n-ary关系提取问题.
最近引入了CombDrugExt数据集,以促进该领域的研究.

研究的目的:

开发和评估一种新的端到端提取方法,用于组合药物治疗.
在药物组合的背景下,改进现有的提取药物关系的方法.
在CombDrugExt数据集上建立一个新的最先进的性能.

主要方法:

采用了一种序列到序列风格的端到端提取模型.
该模型在CombDrugExt数据集上进行了训练和评估.
这种方法在一次通过中进行提取,处理动态的n-ary关系.

主要成果:

拟议的模型在积极组合的CombDrugExt测试集上获得了66.7%的F1得分.
这比以前的非端到端方法绝对提高了约5%的F1分数.
该模型与以前最好的关系分类方法相比,显示出更高的性能.

结论:

开发的端到端提取模型是同类型中的第一个,并为组合药物治疗提取设定了新的最先进的状态.
该模型的单通,动态的n-ary提取能力使其非常适合于现实世界的文献采矿.
这一进步有助于更有效,更准确地从科学文本中识别药物组合.

关键词:

药物组合疗法药物组合疗法从端到端的关系提取.n-ary关系的提取方法命名实体的认可命名实体的认可

更多相关视频

Diagonal Method to Measure Synergy Among Any Number of Drugs

Diagonal Method to Measure Synergy Among Any Number of Drugs

Published on: June 21, 2018

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

相关概念视频

Combined Effects of Drugs: Synergism

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...

Combined Effects of Drugs: Antagonism

Combined Effects of Drugs: Antagonism

The combined effects of drugs can result in various interactions, of which an important type is antagonism. Antagonism is a mechanism where one drug inhibits or counteracts the effects of another drug. Antagonism can occur through various means, including receptor binding, allosteric modulation, functional interaction, chemical reactions, and pharmacokinetic processes.
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...

Drug-Receptor Interactions

Drug-Receptor Interactions

Drug-receptor interaction describes the binding of receptors by drugs, but not all drug-receptor interactions result in activation and tissue response. For instance, the binding of agonists activates the receptor to generate a cellular reaction, while antagonists bind to receptors without causing their activation.
Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue....

Drug Discovery: Overview

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

Drug Nomenclature

Drug Nomenclature

During the development of a new pharmaceutical, the manufacturer initially assigns a code name to the drug. Once approved, the drug receives a United States Adopted Name (USAN)—a generic, nonproprietary designation. Upon being listed in the United States Pharmacopeia, this nonproprietary name becomes the drug's official name. Additionally, the manufacturer assigns a proprietary name or trademark, which serves as the brand name under which the drug is marketed. It is worth noting that...

Drug Biotransformation: Overview

Drug Biotransformation: Overview

Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...