两种植物通过降低安非他成路径的调节来改善地下草食动物的应激反应
Feiyu Zhang1, Yuchen Tan2,3, Zhiyuan Cai1
1Southwest Survey and Planning Institute of National Forestry and Grassland Administration, Kunming, China.
Frontiers in veterinary science
|January 29, 2024
概括
拉迪克斯·阿斯特拉加利 (RA) 和阿坎托帕纳克斯·森蒂科苏斯 (AS) 提取物可以降低被囚禁高原的压力. 这些植物提取物改善了食物摄入量,减少了体重减轻,并调节了压力激素水平和基因通路.
科学领域:
- 动物学 动物学
- 药理学 药理学是指药理学的学科.
- 动物科学动物科学
背景情况:
- 囚禁对于动物的生存和生产力至关重要,但会引起压力,阻碍生长和繁殖.
- 高原 (Eospalax baileyi) 是一种独特的地下草食动物,特别容易受到囚禁环境中的压力.
- 药理干预可以调节压力反应,并有助于养殖和研究.
研究的目的:
- 为了研究Radix astragali (RA) 和Acanthopanax senticosus (AS) 提取物的有效性,以减轻被囚禁的高原鱼的压力.
- 探索RA和AS治疗缓解压力的分子机制.
主要方法:
- 用Radix astragali (RA) 和Acanthopanax senticosus (AS) 提取物给被囚禁的高原.
- 评估生理参数,包括食物摄入量,体重变化和压力激素水平.
- 分析与神经传递和免疫功能相关的基因表达,包括Grin,Prkc和细胞外矩阵-受体相互作用通路.
主要成果:
- 关节炎和AS治疗显著改善了高原时期的食物摄入量,并减少了体重减轻.
- 这两种提取物都有效地降低了与压力相关的行为和循环的压力激素水平.
- RA 和 AS 通过 Grin 和 Prkc 基因家族在下丘脑中抑制了胺诱导的刺激途径.
- 关节炎治疗上调了细胞外矩阵-受体相互作用通路 (Col1a1 / 3a1 / 1a2 / 6a1基因),可能增强免疫功能.
结论:
- 拉迪克斯·阿斯特拉加利 (Radix astragali) 和阿坎托帕纳克斯·森蒂科索斯 (Acanthopanax senticosus) 的提取物有效地减轻了被囚禁的高原鱼的压力.
- 植物提取物通过降低刺激途径和提高免疫相关途径来调节压力反应.
- 这些发现提供了植物性药物的机制,以管理囚禁动物的压力.
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