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在接受牙科植入物的患者中,基因多态,骨损失和骨矿物密度之间的关联
Kaushal Kishor Agrawal1, Neetu Singh2, Pooran Chand1
1Department of Prosthodontics, King George's Medical University, Lucknow, Uttar Pradesh, India.
Journal of Taibah University Medical Sciences
|January 29, 2024
概括
某些介质蛋白基因变异,特别是IL-1B-511 AA和IL-6-572 GG,增加了牙科植入物周围低骨矿物密度 (BMD) 和脊骨损失 (CBL) 的风险.
科学领域:
- 遗传学 是一个遗传学.
- 口腔植入学 在口腔植入学.
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 介质素 (IL) -1 和IL-6基因多态性与骨矿物质密度 (BMD) 的降低有关.
- 系统性BMD和周植入物骨损失 (CBL) 之间的关系需要进一步调查.
- 了解这些遗传因素对于预测植入物成功和管理骨损失至关重要.
研究的目的:
- 调查IL-1和IL-6基因多态和系统性BMD之间的关联.
- 确定这些多态的相关性与牙科植入物周围的围部植入物尖端骨损失 (CBL).
- 为了确定低BMD和与植入物相关的骨损失风险较高的个体的遗传标记.
主要方法:
- 190名接受牙科植入的参与者根据双能X射线吸收计被分为正常的BMD (NBD) 和低的BMD (LBD) 组.
- 在植入后6个月使用形束计算断层扫描来评估形骨损失 (CBL).
- 对IL-1A-889,IL-1B-511和IL-6-572基因多态性进行了基因定型.
主要成果:
- 在低BMD (LBD) 组中,IL-1B-511 AA和IL-6-572 GG基因型的发生频率明显高于正常BMD (NBD) 组.
- 在LBD组中,IL-1B-511 AA和IL-6-572 GG基因型显著与增加的周围植入物骨损失 (CBL) 相关.
- 统计学意义被设定为p<0.05.
结论:
- 具有IL-1B-511 AA或IL-6-572 GG基因型的个体具有骨质疏松症/骨质疏松症的风险增加.
- 这些特定的基因型使个人更容易受到牙植入物周围的骨损失 (CBL) 的影响.
- 对这些多形态的遗传查可能有助于识别患有骨健康不良和植入物并发症风险的患者.
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