门高血压中心脏功能障碍的研究:来自印度东部的单中心经验
Sambit Kumar Behera1, Prajyoti Behera2, Jyoti Ranjan Behera3
1Gastroenterology, Srirama Chandra Bhanja (SCB) Medical College, Cuttack, IND.
Cureus
|January 29, 2024
概括
肝硬化心肌病 (CCM) 在肝病患者中常见,肝病得分较高 (儿童C类或高MELD). 由于肝外原因的门高血压,心脏功能保持正常. 对所有肝硬化患者推进行心声扫描.
科学领域:
- 心脏病学和肝脏病学.
- 研究肝病患者心脏异常的情况.
背景情况:
- 心脏功能异常在肝硬化患者中很普遍.
- 门高血压和肝病对心脏功能的影响需要进一步研究.
- 这项研究评估了肝和非肝门高血压在心脏异常中的作用.
研究的目的:
- 评估肝硬化和非肝硬化门高血压对心脏异常的贡献.
- 为了识别与门高血压的不同原因相关的心脏功能变化.
主要方法:
- 一项横截面的观察性研究,包括128名患有门性高血压的患者 (不包括已知的心脏病).
- 使用心电图 (ECG) 和胸前心电图 (TTE) 评估心脏功能.
- 根据门高血压的原因分类的患者:肝外门静脉阻塞 (EHPVO),Budd-Chiari综合征和肝硬化.
主要成果:
- 在患有EHPVO和Budd-Chiari综合征的患者中观察到正常的心室功能.
- 68%的肝硬化患者表现出腹缩异常.
- 与没有CCM的患者相比,患有肝硬化心肌病 (CCM) 的患者QTc间隔显著增加 (0.49±0.05秒),儿童Turcotte Pugh (CTP) 和MELD得分更高.
结论:
- 较高的CCM患病率与晚期肝病 (儿童C类或高MELD得分) 有关.
- 在患有由肝外原因引起的门性高血压的患者中,心脏功能正常.
- 建议所有肝硬化患者通过心声学进行心脏评估,以指导治疗和移植决策.
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