运动和药物治疗对非酒精性脂肪肝疾病的影响
Amrita Kandel1, Poonam Pant1, Sushila Todi2
1Pharmacy Program, CiST College, New Baneshwor, Kathmandu, Nepal.
SAGE open medicine
|January 29, 2024
概括
运动和药物治疗显著改善了非酒精性脂肪肝 (NAFLD) 标志物. 这两种方法,单独或组合,有效地管理NAFLD,显示生物化学参数的实质性变化.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
- 临床医学 临床医学
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 影响全球人口的20-30%,构成了重大的公共卫生挑战.
- 氧化压力有助于NAFLD的发展和进展,使得像维生素E这样的抗氧化剂成为治疗考虑因素.
- 目前NAFLD的管理策略包括生活方式修改和药物治疗.
研究的目的:
- 评估运动和药物治疗对非酒精性脂肪肝疾病的综合和单独影响.
- 评估正在接受治疗的NAFLD患者的人类测量和生化参数的变化.
- 为了确定非药理和药理干预措施在管理NAFLD时的有效性.
主要方法:
- 在肝脏诊所进行了一项前性3个月的随访研究.
- 包括177名NAFLD患者,并记录了基线特征.
- 使用参数和非参数测试的描述性分析评估了生化参数和治疗关联的变化.
主要成果:
- 观察到体重 (74.88至72.37公斤) 和BMI (28.41至27.31公斤/平方米) 的统计学显著下降.
- 在所有测量的生物化学参数中,都发现了显著的改善 (p < 0.05).
- 非药物学 (运动) 和药物学方法都显示出有效性.
结论:
- 运动和药物治疗是有效的管理非酒精性脂肪肝疾病.
- 这些方法的组合或单独应用导致生物化学标志物的显著改善.
- 这些干预措施为治疗NAFLD和减少与其相关的健康负担提供了可行的策略.
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