减少化疗诱导的外周神经病变的练习:随机对照试验的系统审查和元分析
Yingjie Huang1, Tian Tan2, Lu Liu3
1Guangzhou University of Chinese Medicine, Guangzhou, China.
Frontiers in neurology
|January 29, 2024
概括
运动疗法有效地减少化疗诱导的周围神经病变 (CIPN) 症状,改善癌症患者的生活质量和平衡. 这一元分析证实了运动作为管理CIPN的有益干预措施.
科学领域:
- 在瘤学瘤学.
- 神经学 神经学
- 康复医学 康复医学 康复医学
背景情况:
- 化疗诱导的周围神经病变 (CIPN) 影响超过50%的癌症患者,显著影响生活质量和治疗坚持.
- 运动疗法越来越多地被认为具有减轻CIPN症状和改善患者结果的潜力.
研究的目的:
- 通过对随机对照试验 (RCT) 的元分析,系统地评估运动治疗在治疗化疗诱导的外围神经病变 (CIPN) 中的疗效.
主要方法:
- 在多个数据库 (Embase,Web of Science等) 中进行全面的搜索. 针对CIPN运动治疗的RCT进行了研究,该研究将持续到2022年11月.
- 对于偏差风险评估和元分析,使用了Cochrane手册5.3和Revman 5.3,使用I2测试异质性,使用Stata 15.0.0分析结果.
主要成果:
- 该元分析包括15项与1,124名患者进行的RCT,表明运动治疗显著改善了总症状得分 (SMD: -0.62),麻木,刺痛,生活质量,疼痛和平衡.
- 通过FACT/GOG-NTX问卷评估,运动疗法也对神经毒性产生了积极影响 (p < 0.05).
结论:
- 运动治疗是一种有效的干预措施,可以改善化疗诱导的周围神经病变 (CIPN) 的各个方面,包括症状严重程度,生活质量和平衡.
- 需要进一步的高质量,多中心,大样本的RCT来完善和验证这些发现.
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