肝细胞癌的circRNA和瘤微环境之间的交叉:机制,功能和应用
Chenxi Xie1, Xiaopei Hao2, Hao Yuan1
1Hepatobiliary Center, Department of Hepatobiliary Surgery, People's Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
OncoTargets and therapy
|January 29, 2024
概括
循环RNAs (circRNAs) 是肝细胞癌 (HCC) 发展的关键参与者. 本综述探讨了circRNAs如何与瘤微环境 (TME) 相互作用以影响HCC进展,并讨论了未来的研究途径.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 肝细胞癌 (HCC) 是一种流行性和侵略性的癌症,预后不佳.
- 目前的治疗方法受到缺乏特定的诊断标志物和瘤异质性的限制.
- 循环RNAs (circRNAs) 是具有稳定,特定表达模式的非编码RNA.
研究的目的:
- 审查circRNAs在肝细胞癌 (HCC) 发病和进展中的作用.
- 阐明HCC中circRNAs和瘤微环境 (TME) 之间的复杂交互.
- 确定目前对HCC的circRNA和TME研究的研究缺口和未来方向.
主要方法:
- 关于circRNAs,TME和HCC的现有研究的文献综述.
- 分析circRNAs影响HCC的机制,包括miRNA海绵,蛋白质调制和翻译.
- 讨论TME成分对HCC免疫力,新陈代谢和分泌的影响.
主要成果:
- 循环RNAs通过多种分子机制对HCC的发病和进展做出了重大贡献.
- 瘤微环境 (TME) 极大地影响HCC的代谢,分泌和免疫特征.
- 了解circRNA-TME相互作用对于推进HCC研究和治疗策略至关重要.
结论:
- 循环RNA在HCC中发挥着多方面的作用,与TME有显著的相互作用.
- 需要进一步的研究来解决现有的缺陷和现场争议.
- 未来的研究应侧重于circRNAs和TME对HCC的综合影响,以改善诊断和治疗.
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