有效地制造自组装的多乳酸胆固醇体,用于杀虫剂封装
Zulipiker Payizila1, Fuquan Teng1, Xudong Huang1
1Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology and School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.
ACS omega
|January 29, 2024
概括
我们开发了一种大规模的方法,用于制造可生物降解的多乳酸 (PLA) 合体,以有效地在现场封装. 这些PLA体具有高封装效率和可控制的释放,保护像阿弗梅克丁 (AVM) 这样的封装物质.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 生物技术是生物技术.
背景情况:
- 体体是带有体颗粒外的微囊,具有高效的in situ封装和受控释放的挑战.
- 现有的制造方法难以实现高封装效率和受控释放.
研究的目的:
- 开发一种高效,大规模的方法来制备可生物降解的聚乳酸 (PLA) 体体.
- 为了实现高封装效率和可控释放物质使用这些PLA合体.
- 对于先进的应用来研究PLA合体的形成机制和特性.
主要方法:
- 通过抗溶剂沉合成可生物降解的多乳酸 (PLA) 纳米粒子 (NP).
- 分子动力学 (MD) 模拟以了解NP形成机制.
- 喷雾干燥技术用于构建具有可控制孔性的体体.
- 研究喷雾干燥参数 (入口温度,料速率,空气流量) 影响的自组装机制.
主要成果:
- 成功大规模制备具有可控制外多孔性的PLA合体.
- 使用修改的体体 (平均直径1.57微米) 实现了高封装效率 (89.7%) 和对阿弗梅克丁 (AVM) 的无性.
- MD模拟证实了水蒸发过程中AVM堵塞孔,验证了封装和释放控制.
- 展示了PLA合体的优良紫外线屏蔽特性,保护AVM免受光降解.
结论:
- 建立了一种高效且可扩展的方法来制造可生物降解的PLA体.
- 聚合物聚合物体能够实现高封装效率和受控释放,具有保护敏感化合物的潜力.
- 开发的体体表现出紫外线屏蔽能力,提高了它们在保护性封装应用中的实用性.
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