多种子预防的概念是在实验室中发明的吗?
1Centre for Assisted Fertilization, Naples, 80123, Italy.
概括
与普遍认为的相反,没有证据表明动物卵子中快速阻止多精子症. 精子的进入不受卵细胞等离子体膜脱极化的调节,这挑战了长期以来的受精理论.
科学领域:
- 生殖生物学 生殖生物学
- 细胞生物学 细胞生物学
- 发展生物学 发展生物学
背景情况:
- 快速阻断多精子症的概念,防止多个精子受精卵,已经被广泛接受了几十年.
- 这个想法经常用海受精来说明,海受精是一种广泛研究的生殖过程的模型生物.
- 以前的假设表明,卵细胞脱极化调节了精子的进入,但这现在受到质疑.
研究的目的:
- 重新评估动物卵细胞中多精子症的快速阻断的证据和必要性.
- 调查卵细胞等离子体膜去极化在调节精子进入中的作用.
- 澄清在受精过程中控制多精子预防的机制.
主要方法:
- 关于海受精的历史动力实验的回顾.
- 对卵细胞等离子体膜去极化在多精子症中所扮演的角色的分析.
- 检查决定超数精子命运的事件的时间.
主要成果:
- 没有确的证据支持动物卵细胞中多精子症的快速阻断的存在或必要性.
- 卵细胞等离子体膜去极化似乎没有调节精子的进入,这与之前的建议相反.
- 控制多种子预防的机制尚未完全理解,需要进一步研究.
结论:
- 广泛接受的关于快速阻断多精子症的概念没有得到当前证据的支持.
- 涉及卵细胞脱极化的拟议机制不足以解释多精子预防.
- 需要进一步的研究来确定控制精子进入卵细胞的调节分子机制.
相关概念视频
Spermatogenesis
102.5K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.5K
Fertilization
71.0K
During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
71.0K
Meiosis II
183.4K
Meiosis II is the second and final stage of meiosis. It relies on the haploid cells produced during meiosis I, each of which contain only 23 chromosomes—one from each homologous initial pair. Importantly, each chromosome in these cells is composed of two joined copies, and when these cells enter meiosis II, the goal is to separate such sister chromatids using the same microtubule-based network employed in other division processes. The result of meiosis II is two haploid cells, each...
183.4K


