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Updated: Jul 4, 2025

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
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Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients

Published on: October 15, 2017

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度-QTcF模拟Icenticaftor从一个随机,安慰剂和积极控制的健康参与者的全面QT研究

Ganesh R Iyer1, Borje Darpo2, Hongqi Xue2

  • 1Biomedical Research, Novartis Pharmaceuticals Corporation, Cambridge, MA, USA.

Clinical pharmacology in drug development
|January 29, 2024
PubMed
概括

作为囊性纤维化转膜受体增强剂的Icenticaftor在健康参与者中显示了QTcF间隔的轻微,临床上无意义的缩短. 这项研究评估了其心脏安全性,在治疗剂量或超治疗剂量时没有发现任何影响.

关键词:
在 QT 间隔的长度.在QTc中,QTc是QTc.QTcF 的时间.健康的个人健康的个人一个icenticaftor或一个QBW2511.药理动力学是药理动力学的一个方面.药物动力学 药物动力学再极化再极化是什么意思进行全面的QT研究.

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