怀孕期间库辛综合征的不同表现 - 一个案例系列
Natasha Stoinis1,2, Katherine Creeper1, Jessica Phillips1
1Department of Obstetric Medicine, King Edward Memorial Hospital, Perth, Western Australia, Australia.
The Australian & New Zealand journal of obstetrics & gynaecology
|January 29, 2024
概括
在怀孕期间诊断库辛综合征 (CS) 是具有挑战性的,因为症状重叠. 在怀孕期间未经治疗的CS显著增加了母亲和胎儿的并发症风险,需要密切监测和多学科护理.
科学领域:
- 内分泌学 在内分泌学.
- 产科 产科 产科 产科 产科
- 生殖医学 生殖医学
背景情况:
- 库辛综合征 (CS) 涉及多种原因的高皮质醇症,包括垂体腺瘤,上腺瘤或宫外ACTH/CRH分泌.
- 在怀孕期间诊断CS是困难的,因为共享的症状,如体重增加和纹.
- 在怀孕期间未经治疗的CS对母亲和胎儿都有风险.
研究的目的:
- 审查怀孕期间库辛综合征的临床表现,诊断方法,管理和结果.
- 为了优化临床实践管理CS在孕妇患者.
主要方法:
- 单一中心,对接受产前护理的高皮质醇症妇女进行回顾性审查.
- 从电子和图表审查中收集的数据 (2006-2022年).
- 使用OMNI计算器计算出出生体重.
主要成果:
- 确定了5名妇女和7名怀孕中患有CS的妇女.
- 四个病例涉及来自垂体源的依赖ACTH的CS; 一个是异胎ACTH源.
- 在CS治疗前的怀孕中,出现了二次高血压和糖尿病等并发症.
结论:
- 库辛综合征是罕见的,在怀孕期间难以诊断.
- 如果CS没有治疗,母亲和胎儿的结果会恶化.
- 建议多学科团队参与并密切监测并发症.
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