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在胎儿大脑中基于MRI的扩散曲谱的可复制性

Jiaxin Xiao¹, Cong Sun², Ruike Chen¹

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China.

Journal of magnetic resonance imaging : JMRI

|January 29, 2024

概括

胎儿大脑轨道图的可靠性随着妊娠年龄的增长而下降,在不同白质轨道上观察到显著的变化. 纤维数的可复制性通常很高,但一些区域,如体体的身体,显示出较低的可靠性.

科学领域:

神经成像是一种神经成像.
发育神经科学的发展神经科学.
医学成像分析医学成像分析

背景情况:

扩散核磁共振 (dMRI) 轨道图对于研究发育中的白质量至关重要.
在子宫内dMRI面临诸如运动工件和低分辨率等局限性,影响胎儿大脑轨道图的可靠性.
以前的研究几乎没有调查胎儿大脑轨道图的可靠性.

研究的目的:

为了在胎儿大脑中确定可靠可追溯的白质纤维.
评估管道再生能力如何随妊娠年龄 (GA) 变化.
为了确定管道复制性是否在不同大脑区域之间有所不同.

主要方法:

44个健康胎儿 (GA 25-37周) 的前性队列研究.
使用3T dMRI进行重复扫描和受约束的球形解卷建模.
分析了八种主要白质纤维的通道图复制性,比较了早期 (≤30周) 和晚期 (>30周) 的GA组.

主要成果:

前丘脑辐射的可复制性,下纵向囊 (ILF),体基因 (GCC) 和体体 (BCC) 的可复制性随着GA的进展显著下降.
皮质脊髓管,下面的前后囊和GCC显示出高纤维数的可重复性 (平均Dice>0.81).
在早期和晚期的GA组中,BCC和ILF表现出最低的可复制性.

结论:

胎儿大脑轨道图的可靠性取决于妊娠年龄.
白质管道识别的可重现性在不同大脑区域之间有很大差异.
这些发现强调了在解释胎儿dMRI通道图时需要考虑GA和特定纤维特性.

关键词:

这是一个dMRI.胎儿大脑胎儿大脑纤维纤维纤维纤维纤维是一种纤维.可复制性的可复制性路径学路径学路径学路径学路径学

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Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...