乳酸细菌发酵对牛奶过敏性和抗原性的影响:一篇综述
Yunpeng Xu1, Feifei Zhang2, Guangqing Mu3
1School of Food Science and Technology, Dalian Polytechnic University, Dalian, Liaoning, P. R. China.
Comprehensive reviews in food science and food safety
|January 29, 2024
概括
乳酸细菌 (LAB) 发酵可以通过分解过敏原表位和调节免疫系统来减少牛奶过敏 (CMA). 需要进一步的研究,以充分阐明开发有效干预措施的机制.
科学领域:
- 食品科学与技术 食品科学与技术
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 牛奶过敏 (CMA) 是一个严重的健康问题,主要是由牛奶中的特定过敏原成分引起的.
- 乳酸细菌 (LAB) 和它们的发酵产品在治疗过敏症方面表现有前途.
- LAB的免疫调节和增强屏障的特性是其潜在抗过敏作用的关键.
研究的目的:
- 审查牛奶中的线性过敏原表位.
- 检查LAB发酵对这些牛奶过敏原的影响.
- 探索预测过敏原表位的方法,并总结LAB在缓解CMA方面的机制.
主要方法:
- 关于牛奶过敏原和LAB干预措施研究的文献综述.
- 分析LAB对免疫系统调节和肠道屏障功能的影响.
- 传统实验室分析与分子模拟的整合,用于表位预测.
主要成果:
- 在LAB发酵过程中,过敏原的表位物被水解,从而降低了它们的过敏性.
- LAB调节宿主免疫反应,可能预防或减轻过敏反应.
- LAB增强了肠道屏障的功能,限制了过敏原的吸收.
结论:
- LAB发酵提供了一种有前途的策略,通过表皮质水解和免疫调节来减少CMA.
- 了解LAB行动的精确机制对于制定有针对性的预防和治疗策略至关重要.
- 这一审查为进一步研究和应用基于LAB的CMA干预措施提供了基础.
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