在COVID-19期间和之后,生物化学和代谢参数的时间过程
Zohreh-Al-Sadat Ghoreshi1,2,3, Mojtaba Abbasi-Jorjandi3,4, Gholamreza Asadikaram3,4
1Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran.
COVID-19 感染会改变生化标志物,变化因疾病严重程度和性别而异. 虽然一些标志物在感染后正常化,但其他标志物会持续存在,可能表明长期的COVID风险.
科学领域:
- 生物化学 生化学
- 传染性疾病 传染性疾病
- 临床医学 临床医学
背景情况:
- 长期COVID是一个持续的症状状况后SARS-CoV-2感染,显著影响患者的健康.
- 了解COVID-19的生物化学基础及其长期后果对于患者管理至关重要.
研究的目的:
- 为了研究SARS-CoV-2感染后生物化学标记物的纵向变化.
- 评估疾病严重程度,性别和生化变化之间的关系.
- 探索死亡率和长期COVID的潜在预测因素.
主要方法:
- 一项对470名SARS-CoV-2患者的纵向研究,根据疾病严重程度 (中度,严重,危急) 分类.
- 测量空腹血糖 (FBS),肝酶 (SGPT,SGOT),功能标记物 (肌素,尿素),尿酸 (UA),总蛋白质 (TP), (Zn) 和血红蛋白A1c (HbA1c).
- 在住院期间和感染后1个月和3个月进行了生化评估.
主要成果:
- COVID-19的严重程度与葡萄糖,尿素,肌素,ALT,AST,ALP和HbA1c的升高以及Zn,UA和TP的降低相关.
- 在所有时间点中,这些标记物中观察到基于性别的显著差异.
- 葡萄糖,尿素,肌素,ALT,AST和ALP等标记物减少了三个月,而UA和TP水平接近正常.
结论:
- SARS-CoV-2 感染诱导了取决于性别的生化变化,随着疾病的严重程度而加剧,并可以预测死亡率.
- 虽然许多标记物在急性感染后正常化,但在三个月后,有些仍然异常,这表明潜在的长期影响.
- 需要进一步的研究来确定这些生化轨迹是否预测长期COVID的发展.
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