血托科菲罗和肺癌风险之间的关联:来自南方社区队列研究的结果
Hyung-Suk Yoon1,2,3, Jie Wu1, Chris Shidal1
1Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
概括
较高的血总托科菲罗尔水平与肺癌风险降低有关,特别是在欧洲裔美国人和目前的吸烟者中. 然而,关联可能因多科菲罗尔异构体和种族而异,需要进一步研究.
科学领域:
- 营养生物化学 营养生物化学
- 癌症流行病学 癌症流行病学
背景情况:
- 托科菲醇是维生素E的一种形式,具有抗癌性质.
- 有限的数据存在于托科菲罗尔在非洲裔美国人 (AA) 和欧洲裔美国人 (EA) 肺癌风险中的作用.
- 肺癌不成比例地影响低收入AA和EA人群.
研究的目的:
- 为了研究血中托科菲罗尔水平与肺癌风险之间的关联.
- 根据种族和托科菲罗尔异构体来检查这种关联中的潜在差异.
主要方法:
- 在南方社区队列研究中进行了一个嵌套的病例控制研究.
- 使用高性能液态染色学测量了四种多科菲罗尔异构体 (α-, β/γ-, δ-,总) 的血水平.
- 使用条件后勤回归来估计几率比率 (OR) 和95%置信区间 (CI),调整为混因素.
主要成果:
- 总体而言,较高的血总托科菲罗尔水平与肺癌风险相反相关 (OR = 0.51).
- 在欧洲裔美国人,男性,当前吸烟者以及在抽血后2年内被诊断出来的人群中观察到显著的反向关联.
- 在非洲裔美国人中没有发现显著的风险降低,但在α-托科菲罗和种族之间注意到了显著的相互作用.
结论:
- 血总托科菲罗尔与肺癌风险有相反的关联.
- 这种关联可能会受到多科菲罗尔异构体类型,种族和个体特征的影响.
- 需要进一步的大规模研究来验证这些发现,并为预防策略提供信息.
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