慢性胰腺炎中的系统性中性粒细胞凝酶相关的利波卡林变化:一个多中心,横截面的研究
Kristyn Gumpper-Fedus1,2, Kaylin Chasser1,2, Valentina Pita-Grisanti1,2,3
1Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Clinical and translational gastroenterology
|January 29, 2024
概括
作为慢性胰腺炎 (CP) 的生物标志物,中性细胞凝酶相关的卡林 (NGAL) 是有前途的. 在CP患者中增加的NGAL和特定脂肪酸变化提供了新的诊断见解.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 代谢学 代谢学 代谢学
背景情况:
- 慢性胰腺炎 (CP) 是一种衰弱的纤维炎症疾病,缺乏有效的治疗方法和诊断标志物.
- 中性细胞凝酶相关的卡林 (NGAL),一种促炎性细胞因子,结合脂肪酸 (FA) 并参与炎症过程.
研究的目的:
- 研究血NGAL和FA概况作为CP的潜在生物标志物.
- 探索NGAL,FA和CP患者的代谢变化之间的关系.
主要方法:
- 在171名参与者 (对照组,急性/复发性急性胰腺炎,CP) 中使用免疫试验量化了血NGAL水平.
- 用气相色谱分析了等离子FA组成.
- 周围血液单核细胞 (PBMC) NGAL表达通过细胞计量通过飞行时间来评估.
主要成果:
- 与对照组和急性胰腺炎患者相比,CP患者的血NGAL显著升高.
- 表达NGAL的PBMC有效地将CP患者与控制组和急性胰腺炎组区分开来.
- 在CP中观察到脂肪酸的特定变化,包括较低的烯酸和较高的基-γ-烯酸和上腺酸.
结论:
- 血NGAL升高和不同的NGAL+PBMC概况表明它作为CP的诊断生物标志物的作用.
- NGAL和FA之间的相互作用可能会阐明CP的代谢病理生理学,从而有可能改善诊断分类.
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