在患有骨转移疼痛的肺癌患者中改变了灰质体积和功能连接性
Yu Tang1, Yumei Shi2, Zhen Xu2
1Department of Radiology, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, China.
Journal of neuroscience research
|January 29, 2024
概括
骨转移疼痛 (BMP) 与大脑结构变化有关,包括在特定区域减少灰质体积. 这些变化可能会影响疼痛控制,认知和情绪处理.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 在瘤学瘤学.
背景情况:
- 骨转移疼痛 (BMP) 是一种严重的慢性疼痛疾病.
- 以前的研究表明,BMP中存在功能性大脑异常.
- BMP对大脑结构和功能网络的影响尚不清楚.
研究的目的:
- 调查BMP和没有BMP的患者的灰质体积 (GMV) 和功能连接 (FC) 差异.
- 探索转基因病毒变化与临床变量之间的关系.
- 为BMP机制提供神经成像证据.
主要方法:
- 基于voxel的形态测量和功能连接 (FC) 分析.
- 肺癌患者的GMV和FC与BMP,没有BMP和健康对照进行比较.
- 皮尔森相关性和接收器运行特征 (ROC) 分析.
主要成果:
- 与健康对照组相比,BMP(+) 患者在中侧额头 (MFG) 和右侧中侧 (MTG) 中显示GMV降低.
- 与BMP(-) 患者相比,BMP(+) 患者在小脑_6_L和左舌环中减少了GMV.
- 在BMP(+) 患者中,在MFG/右MTG和小脑之间观察到增强的FC.
结论:
- BMP与显著的大脑变化有关,包括减少的GMV和改变的FC.
- 这些变化可能会影响疼痛调节,认知功能,情绪控制和感觉运动处理.
- 小脑在疼痛处理中的作用需要进一步研究.
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