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痴迷强迫症患者中改变的半球间功能连接性及其在治疗反应预测中的潜力

Haohao Yan¹, Yingying Zhang¹, Xiaoxiao Shan¹

¹Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China.

Journal of neuroscience research

|January 29, 2024

概括

顶顶叶叶片和后中枢回形中的voxel-mirrored homotopic connectivity (VMHC) 变化与强迫症 (OCD) 病理生理学有关. 后中枢环中的VMHC可以预测强迫症患者对帕洛克塞的治疗反应.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
放射学放射学是一门学科.

背景情况:

强迫症 (OCD) 是一种令人虚弱的心理健康状况.
在强迫症病理生理学和治疗反应中,声镜镜同型连接 (VMHC) 的作用尚未完全理解.

研究的目的:

使用VMHC调查强迫症的病理生理机制.
为了确定潜在的生物标志物来预测强迫症患者的治疗疗效.

主要方法:

磁共振成像 (MRI) 用于在没有药物治疗的强迫症患者和健康对照者 (HC) 中评估VMHC.
在帕洛克塞丁治疗4周后,患者被重新扫描.
使用了支持向量回归 (SVR) 和相关性分析.

主要成果:

与HC患者相比,强迫症患者在双边上顶叶 (SPL),中后回形和皮质中表现出较低的基线VMHC.
后中环中的VMHC与认知功能正相关.
帕洛克塞丁治疗导致背带皮质/前皮质 (PCC/PCu) 的VMHC增加,症状改善.
基线VMHC在后中环预测治疗反应.

结论:

SPL,中后回形和皮质都与强迫症病理生理学有关.
PCC/PCu参与了强迫症治疗的药理机制.
后中枢环中的VMHC显示出作为强迫症治疗结果的预测生物标志物的潜力.

关键词:

背部注意网络的背部注意网络.传感器运动网络的传感器.视觉网络视觉网络是一个视觉网络.沃克塞尔镜像同位体连接 voxel 镜像同位体连接

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