对食物过敏的表观遗传学和表观遗传学研究
Yoojin Chun1, Jo Hsuan Lee1, Supinda Bunyavanich1,2
1Department of Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
概括
表观遗传学,包括DNA甲基化,提供了对食物过敏发展和严重性的见解. 表观遗传标记可以作为管理食物过敏的生物标记.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
- 分子生物学分子生物学
背景情况:
- 表观遗传学提供了遗传倾向,环境因素和食物过敏结果之间的联系.
- 了解表观遗传机制对于阐明食物过敏病原发生至关重要.
研究的目的:
- 审查与已确定的临床食物过敏相关的表观遗传位置的基于人口的研究.
- 突出表观基因组和候选基因调查的发现.
主要方法:
- 对基于人群的研究进行审查,研究食物过敏中的表观遗传机制 (DNA甲基化,microRNA).
- 对全表观基因组关联研究 (EWAS) 和候选基因研究的分析.
主要成果:
- 全表观基因组研究确定了与T细胞发育,抗原呈现和反应严重程度相关的差异甲基化位点.
- 候选基因研究揭示了与T细胞调节活性和细胞因子产生相关的基因中的甲基化变化.
结论:
- 表观遗传位置与食物过敏机制和严重程度有关.
- 表观遗传标记物显示出作为食品过敏临床管理的生物标记物的潜力.
- 需要进一步的基于人口的表观基因组研究来进一步理解.
关键词:
生物标志物生物标志物蛋过敏 过敏对蛋的过敏这是表观遗传学.全表观基因组协会研究研究.在表观遗传学上,表观遗传学是指食物过敏 食物过敏甲基化处理的方法这是一个小RNARNA.牛奶过敏 牛奶过敏对于花生过敏的过敏更多相关视频
07:10Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
Published on: April 21, 2019
16.4K
04:34Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
Published on: September 14, 2018
25.6K
相关概念视频
02:06Allergic Reactions
27.4K
Overview
27.4K
00:42Cross-reactivity
31.1K
Overview
31.1K
01:37Epigenetic Regulation
3.0K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.0K
01:20Gene-Environment Interactions
319
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
319
01:10Antibody Structure
60.1K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
60.1K