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Updated: Jun 23, 2026

Growth Assays to Assess Polyglutamine Toxicity in Yeast
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基于病毒的动物模型在多重氨酸乱中

Carina Henriques1,2,3,4, Miguel M Lopes1,2,3,5, Ana C Silva1,2,3,5

  • 1Center for Neuroscience and Cell Biology (CNC), Gene and Stem Cell Therapies for the Brain Group, University of Coimbra, 3004-504 Coimbra, Portugal.

Brain : a journal of neurology
|January 29, 2024
PubMed
概括

病毒载体提供了一种灵活而有效的方法,用于创建多重氨酸乱的动物模型. 这种方法补充了转基因模型,有助于研究这些不可治愈的神经退行性疾病.

关键词:
腺相关的载体.大脑大脑大脑的大脑大脑它们是lentiviral 载体.神经退行性疾病的神经退行性疾病非人类灵长类动物.动物 动物 动物

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...