青少年使用大麻和焦虑症状和障碍:系统性审查和元分析
Darby J E Lowe1, Maryam Sorkhou1,2, Tony P George1,2,3
1Addictions Division, Centre for Addiction and Mental Health (CAMH), Toronto, Canada.
The American journal of drug and alcohol abuse
|January 29, 2024
概括
青少年使用大麻与晚年发展焦虑症和症状的风险更高有关. 这一系统性审查强调了解决与早期大麻消费相关的心理健康风险的重要性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 大麻使用在青少年中很普遍,这是神经生物学和心理过程的关键发展时期.
- 青少年特别容易受到大麻的影响,因为他们的发育可塑性较高.
- 大麻使用和焦虑症之间存在很高的并发症,早期证据表明大麻可能会在焦虑症的发展之前出现.
研究的目的:
- 系统地审查和元分析青少年大麻使用和随后的焦虑结果之间的潜在关联.
- 检查青少年大麻使用与焦虑障碍和/或症状发生率之间的关系.
主要方法:
- 按照PRISMA指南进行的系统审查和元分析.
- 分析了截至2022年9月发表的纵向研究数据.
- 包括六项用于定量元分析的研究和十二项用于定性审查的研究,总共有18项研究,涉及33380名受试者.
主要成果:
- 分析显示,青少年大麻使用与随后焦虑障碍的发展之间存在显著的关联 (OR=2.14,95% CI:1.37-3.36,p<.01).
- 十二项纵向研究的定性综合表明,九项研究观察到青少年大麻使用与焦虑症状恶化之间存在显著的关系.
- 调查结果在定量和定性分析中是一致的,表明了潜在的联系.
结论:
- 目前的证据支持青少年大麻使用与以后的焦虑症状和障碍之间的潜在关联.
- 强调需要改进研究方法,考虑基于性别的差异,并控制混因素.
- 强调教育举措和临床干预措施的重要性,以减轻青少年大麻使用对心理健康的风险.
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