工程聚乙烯甘醇颗粒用于向药物输送
Shiyao Li1,2, Yutian Ma3, Jiwei Cui4
1School of Science, RMIT University, Melbourne, Victoria 3000, Australia. david.ju@rmit.edu.au.
Chemical communications (Cambridge, England)
|January 29, 2024
概括
聚乙烯甘醇 (PEG) 颗粒是药物输送的关键,增强循环时间,减少非目标分布. 本综述涵盖了PEG粒子合成,特性和针对性治疗中的应用.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 聚乙烯甘醇 (PEG) 是药物输送应用中的基准"隐形"聚合物.
- 颗粒的PEGylation延长了循环,并减少了由于其低污染和隐蔽特性而导致的非特异生物分布.
- 将向和药物加载能力整合到基于PEG的颗粒中,对于在目标地点有效积累至关重要.
研究的目的:
- 审查聚乙烯糖醇 (PEG) 颗粒的合成最近的进展.
- 探索PEG粒子物理化学性质对隐形和准有效性的影响.
- 突出PEG颗粒在向药物输送系统中的应用.
主要方法:
- 专注于合成方法,以创建PEG主导粒子.
- 对粒子特性如何影响*in vivo*行为进行分析.
- 综述了使用PEG颗粒证明向药物输送的研究.
主要成果:
- PEG粒子在延长血液循环时间方面表现出显著的潜力.
- 可以调整PEG颗粒的物理化学特性,以提高隐形性和准性.
- 在向药物输送中的成功应用突显了PEG颗粒的治疗前景.
结论:
- PEG颗粒在药物输送方面非常有效,提供了改善的药理动力学和生物分布.
- 定制PEG粒子合成和特性是优化向治疗结果的关键.
- 对PEG粒子工程的持续研究将推动有针对性的药物输送策略.
更多相关视频
11:32Characteristics of Precipitation-formed Polyethylene Glycol Microgels Are Controlled by Molecular Weight of Reactants
Published on: December 23, 2013
11.9K
10:38Synthesis of Functionalized 10-nm Polymer-coated Gold Particles for Endothelium Targeting and Drug Delivery
Published on: January 15, 2018
12.6K
相关概念视频
01:24Modified-Release Drug Delivery Systems: Site-Targeted
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...