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社区型肝炎的流行率被高估:一个前性,出生队列研究
P Aiden McCormick1, Marie O'Grady2, Cillian F De Gascun3
1National Hepatitis C Treatment Program HSE, Liver Unit, St. Vincent's University Hospital and UCD, Elm Park, Donnybrook, Dublin 4, DO4 T6F4, Ireland. a.mccormick@ucd.ie.
Irish journal of medical science
|January 29, 2024
概括
在爱尔兰,肝炎C病毒 (HCV) 感染的流行率.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 型肝炎病毒 (HCV) 感染通常无症状,导致未被诊断的病例.
- 建议基于社区的出生队列查用于识别感染个体.
- 爱尔兰1965-1985年出生队列中估计的HCV流行率为0.7-1%,影响了查的成本效益.
研究的目的:
- 为了确定型肝炎病毒感染的社区流行率.
- 专注于1965年至1985年之间出生的人的特定出生队列.
主要方法:
- 从全科医生血液测试中取出的匿名血清样本被分析为HCV抗体和抗原.
- 测试包括14320个样本,其中9347个来自目标1965-1985年出生队列.
- 参与者包括爱尔兰各地的12家主要通用医院.
主要成果:
- 在1965年至1985年的出生队列中,HCV抗原的总流行率为0.09%.
- 在两个都柏林城市地区的男性中观察到0.39%的更高患病率.
- 在72个抗体阳性样本中,12个 (17%) 也是抗原阳性.
结论:
- HCV血清流行率明显低于之前的估计.
- 低于预期的抗原阳性表明有效的治疗或自发的病毒清除.
- 普遍的出生队列查不太可能具有成本效益;在高患病率地区可以考虑针对性的查.
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