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Updated: Jul 4, 2025

Artificial RNA Polymerase II Elongation Complexes for Dissecting Co-transcriptional RNA Processing Events
10:59

Artificial RNA Polymerase II Elongation Complexes for Dissecting Co-transcriptional RNA Processing Events

Published on: May 13, 2019

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植物聚合酶-关联因子1复杂链接转录和H2B单双化全基因组

Noel Blanco-Touriñán1, Jaime Pérez-Alemany1, Clara Bourbousse2

  • 1Instituto de Biología Molecular y Celular de Plantas (CSIC-UPV), 46022 Valencia, Spain.

Plant physiology
|January 29, 2024
PubMed
概括

在阿拉比多普西斯中,聚合酶相关因子1复合体 (Paf1C) 对于转录延长至关重要. 它调节RNA聚合酶II (RNAPII) 的进展和素H2B单双化,这对基因表达至关重要.

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相关概念视频

Transcription Elongation Factors02:35

Transcription Elongation Factors

Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
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General Transcription Factors01:30

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Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
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Spreading of Chromatin Modifications02:25

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The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
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