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Updated: Jul 4, 2025

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在重症监护病房的重症监护病房中爆发了抗药性blaOXA-69/blaOXA-23/blaGES携带Acinetobacter baumannii ST2的疫情

Anis Raddaoui^1,2, Aymen Mabrouk^1,2, Yosra Chebbi^1,2

¹1Laboratory Ward, National Bone Marrow Transplant Center, 1006 Tunis, Tunisia.

Acta microbiologica et immunologica Hungarica

|January 29, 2024

概括

抗药性杆菌 Acinetobacter baumannii (PDR-A. 抗药性杆菌 Acinetobacter baumannii (PDR-A. 抗药性杆菌 Acinetobacter baumannii) 是一种抗药性杆菌. 在ICU中爆发的疫情凸显了系统查的必要性. 环境污染,包括呼吸器,在PDR-A中发挥了作用. 人类传播. 人类传播.

科学领域:

传染性疾病传染性疾病
微生物学微生物学
公共卫生公共卫生

背景情况:

宝曼尼菌 (Acinetobacter baumannii) 是一个显著的医院病原体,抗生素耐药性正在增加.
这种抗药性A. baumannii (PDR-A. 在医疗保健机构,特别是重症监护室 (ICU) 中,巴曼尼 (baumannii) 构成严重威胁.
一个PDR-A.疫情爆发. 突尼斯一家ICU的baumannii导致患者死亡,需要紧急调查.

研究的目的:

调查PDR-A的来源和传播. 在突尼斯的一个ICU中爆发了baumannii疫情.
描述抗微生物耐药性机制和PDR-A的遗传相关性. 宝曼尼的分离物.
评估环境污染在PDR-A传播中的作用. 曼尼. 曼尼. 这是一个很好的选择.

主要方法:

从患者和ICU环境表面中分离和识别A. baumannii.
抗微生物敏感性测试 (EUCAST指导方针) 和最小抑制度 (MIC) 的确定.
聚合酶链反应 (PCR) 用于β-乳糖酶/碳酶和mcr基因的检测.
脉冲场凝电泳 (PFGE) 和多位数序列类型 (MLST) 用于遗传相关性分析.

主要成果:

有九个PDR-A. 从四名患者和环境样本 (洗手盆,手部消毒剂,呼吸器) 中恢复了baumannii分离物.
所有的PDR-A. 宝曼尼分离物中含有blaOXA-69基因;其中七个还含有blaGES和blaOXA-23基因. 没有检测到mcr基因.
PFGE确定了四种脉冲型,其中脉冲型A (ST2克隆) 包含七种PDR-A. 从患者和环境来源中分离出来的 baumannii.
疫情与流行性克隆ST2有关,环境污染,包括呼吸器,有助于传播.

结论:

环境污染,特别是使用呼吸器等设备的污染,可以促进PDR-A的传播. 在ICU中的baumannii.
在研究的PDR-A.中,blaOXA-69,blaGES和blaOXA-23基因普遍存在. 宝曼尼菌株. 的人类菌株.
系统查多药耐药性 (MDR) 和PDR-A. 宝曼尼对控制医疗保健机构传播至关重要.

关键词:

在ICU中,医生会对患者进行治疗.这些伤害是伤害的.这就是blaOXA-23的原因.疫情爆发的原因是这种抗药性Acinetobacter baumannii的病原体.

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