流动会影响等离子体凝块中纤维素网络的结构和机械特性
Hande Eyisoylu1,2, Emma D Hazekamp3, Janneke Cruts3
1Department of Hematology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
流体流动显著影响血栓形成. 在流动下形成的凝块表现出更密集的纤维素网络和增加的性,这对于理解血栓性疾病和血栓切除术结果至关重要.
科学领域:
- 生物医学工程 生物医学工程
- 血液学 血液学 血液学
- 生物物理学的生物物理.
背景情况:
- 血栓主要由纤维素网络组成,其特性影响了血栓性疾病.
- 当前的研究往往忽视了血液流动对凝块形成的影响,使用静态模型.
- 纤维素的机械稳定性与血栓形成中的网络特性变化有关.
研究的目的:
- 研究流体流动对等离子体凝块结构和机械性能的影响.
- 为了在静态和动态 (流动) 条件下比较纤维素凝块形成.
- 确定流动在开发生理学上相关的体外血栓模型中的重要性.
主要方法:
- 在静态 (0 RPM) 和流量 (30 RPM) 条件下,Chandler循环中的准备好的血凝块.
- 通过扫描电子显微镜和共聚焦显微镜来描述凝块结构.
- 通过无限制的压缩测试评估机械刚性,量化纤维密度,孔径大小和纤维厚度.
主要成果:
- 与静态凝块相比,在流动下形成的凝块显示纤维素纤维较薄,毛孔较小.
- 流动诱导的血块表现出更密集的纤维素网络和显著更高的刚性.
- 纤维密度,孔径大小,纤维厚度和散体刚度在不同应变值的量化差异.
结论:
- 流体流动是确定纤维素凝块结构和机械性能的一个关键因素.
- 静态体外模型可能无法准确地代表体内血栓形成.
- 考虑液体流动对于在血栓切除研究和栓塞风险评估中准确的血栓建模至关重要.
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