对振动毛细管雾化器 (VCN) 和商用接口进行线上合毛细管电泳与ICP-MS的比较研究
Tristen L Taylor1, Dariya Tukhmetova2, Thi Phuong Thanh Duong2,3
1Department of Chemistry, Iowa State University, Ames, IA, USA.
Analytical and bioanalytical chemistry
|January 29, 2024
概括
一种新的振动毛细管雾化器 (VCN) 为毛细管电泳-诱导合等离子体质谱法 (CE-ICP-MS) 分析提供了更好的基线稳定性和可重复性. 虽然灵敏度较低,但它为物种分析提供了与商业雾化器相比较的检测极限.
科学领域:
- 分析化学 分析化学
- 频谱学是一种光谱学.
- 环境分析 环境分析
背景情况:
- 毛细电泳 (CE) 与感应合的等离子体质谱 (ICP-MS) 结合,对于元素物种化至关重要.
- 气动雾化器可以限制CE-ICP-MS系统的性能.
- 一种新型的振动毛细血管雾化器 (VCN) 提供了一种独立于气体流量的替代方案.
研究的目的:
- 为了评估新的振动毛细血管雾化器 (VCN) 在线CE-ICP-MS合的性能.
- 为了将VCN与两台商用气动雾化器进行比较,用于河水中的硫酸盐分析.
- 使用不同类型的雾化器来确定CE-ICP-MS的优点数字.
主要方法:
- 毛细管电泳 (CE) 与感应合的等离子体质谱 (ICP-MS) 的在线合.
- 使用了一种新的振动毛细血管雾化器 (VCN) 和两个商用气动雾化器.
- 进行了河水中硫酸盐的复制分析,并分析了校准标准.
主要成果:
- CE-VCN-ICP-MS设置的灵敏度降低了2至4倍,但噪声水平降低.
- 基于VCN的设置显示出优越的线性相关性和最高的基线稳定性 (2.7% RSD).
- 与商业设置相比,实现了无法区分的检测极限 (LOD) 和量化极限 (LOQ).
- 观察到VCN具有很高的可重复性 (峰值区域的RSD为4.1%).
结论:
- 振动毛细血管雾化器 (VCN) 是CE-ICP-MS分析的可行,低成本的替代方案.
- VCN提供了增强的基线稳定性和可重复性,这对于准确的物种化至关重要.
- 尽管灵敏度较低,但VCN提供了可比的LOD/LOQ值,使其适合环境水分析.
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