探索缺血性中风中氧化应激的研究趋势和热点 (2001-2022):从文献计量学的见解
Nan Jiang1, Ting Yang1, Hongxia Han2
1Department of Neurology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, Shanxi, China.
Molecular neurobiology
|January 29, 2024
概括
氧化应激显著影响缺血性中风病理,但临床抗氧化剂治疗面临挑战. 这项研究绘制了研究趋势的地图,识别了新出现的热点,如铁亡,并为未来的治疗策略提供了信号途径.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 病理学 病理学 病理学
背景情况:
- 氧化应激是缺血性中风和缺血-再输液损伤的关键因素.
- 对缺血性中风的临床抗氧化疗法已经显示出不一致的有效性.
- 了解研究趋势对于开发有效的抗氧化剂策略至关重要.
研究的目的:
- 进行对缺血性中风中氧化应激研究的文献分析.
- 确定关键的研究趋势,主题,热点和该领域的演变.
- 为未来的缺血性中风的临床抗氧化剂治疗策略提供信息.
主要方法:
- 在科学网络核心收藏中对2001-2022年出版物进行文献计量分析.
- 使用VOSviewer可视化和分析发展趋势和热点.
- 识别主要的国家,机构,期刊和研究主题.
主要成果:
- 从2001年到2022年,关于氧化应激和缺血性中风的出版物显著增加.
- 中国和美国在出版量方面处于领先地位;斯坦福大学是一个富有成效的机构.
- 关键主题包括炎症,线粒体损伤,反损伤和认知障碍.
- 新出现的热点包括NLRP3炎症体,自,线粒,miRNA,铁和信号通路.
- 在多目标监管方面取得了进展,但临床翻译仍然是一个挑战.
结论:
- 关于缺血性中风中氧化应激的研究正在迅速扩大,中国和美国的贡献很大.
- 新兴的研究热点表明,人们正在转向复杂的机制,如铁和信号通路.
- 未来的临床治疗可能受益于多目标策略和新技术,如纳米材料,以更好地整合氧化应激管理.
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