Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

1.3K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Enhance summer stress resilience and photosynthetic efficiency of grapevines through foliar application of silicon and kaolin combination.

BMC plant biology·2026
Same author

Whole-Mount Immunostaining of Tyrosine Hydroxylase for Dopaminergic Neuron Analysis in Zebrafish Larvae.

Bio-protocol·2026
Same author

Cardiac Modulation by <i>Santolina chamaecyparissus</i> Aqueous Extract in a Rat Model of Mammary Carcinogenesis.

Current issues in molecular biology·2026
Same author

Toxicological Activities of <i>Pteridium aquilinum</i> Rhizomes and Fiddleheads in HPV16-Transgenic Mice.

Biology·2026
Same author

The effects of long-term aerobic exercise on prostate cancer-induced adipose tissue wasting: Browning to the rescue?

Cellular signalling·2026
Same author

Strengthening animal welfare: monitoring humane endpoints in a rat model of mammary tumorigenesis undergoing a ladder resistance training protocol.

Laboratory animals·2026

相关实验视频

Updated: Jul 4, 2025

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
17:28

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

12.6K

关于发育毒性测试的指导方针:简要见解

Sofia Alves-Pimenta1,2, Luís Félix3,4, Bruno Colaço1,2

  • 1Department of Animal Science, School of Agrarian and Veterinary Sciences (ECAV), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal.

Methods in molecular biology (Clifton, N.J.)
|January 29, 2024
PubMed
概括

发展性毒理学研究正在转向替代测试方法,以减少动物使用. 虽然体外和非哺乳动物模型显示出希望,但它们目前补充,而不是取代,用于生殖毒性评估的传统体外研究.

关键词:
替代方法选替代方法选动物模型动物模型发展性毒性 发展性毒性药物安全性评估 药物安全性评估危害健康的风险 健康风险测试 测试 测试 测试

更多相关视频

Rapid Evaluation of Toxicity of Chemical Compounds Using Zebrafish Embryos
00:07

Rapid Evaluation of Toxicity of Chemical Compounds Using Zebrafish Embryos

Published on: August 25, 2019

10.7K
Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure
08:25

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

Published on: June 5, 2020

6.8K

相关实验视频

Last Updated: Jul 4, 2025

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
17:28

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

12.6K
Rapid Evaluation of Toxicity of Chemical Compounds Using Zebrafish Embryos
00:07

Rapid Evaluation of Toxicity of Chemical Compounds Using Zebrafish Embryos

Published on: August 25, 2019

10.7K
Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure
08:25

Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

Published on: June 5, 2020

6.8K

科学领域:

  • 发展性毒理学 发展性毒理学
  • 生殖毒理学 生殖毒理学
  • 监管科学是一种监管科学.

背景情况:

  • 确保人类健康和环境安全需要对新物质进行严格的生殖和发育毒性测试.
  • 传统的体内哺乳动物模型提供了全面的评估,但面临着越来越多的伦理和监管压力,以减少脊椎动物的使用.
  • 该领域正在积极寻找和验证替代测试策略,以满足这些不断变化的需求.

研究的目的:

  • 审查和描述用于生殖和发育毒性测试的标准和替代方法的批准指南.
  • 讨论开发和验证用于生殖毒性终点的替代试验的挑战和进展.
  • 评估这些测试策略的当前监管和科学状态.

主要方法:

  • 审查现有的文献和发展和生殖毒性测试的监管指南.
  • 列举和简要描述标准体内和新兴的体外和非哺乳动物试验模型中的标准体内和新兴的替代试验模型.
  • 分析各种测试方法的科学和监管地位.

主要成果:

  • 生殖毒性评估是复杂的,由于涉及生育和发育的复杂机制,很难完全用替代方法来代替.
  • 包括体外系统和非哺乳动物物种在内的替代模型正在推进,但在验证和可预测性方面面临障碍.
  • 目前的替代策略预计将在不久的将来减少,但不会完全取代体内动物对生殖毒性的试验.

结论:

  • 开发和验证替代测试方法对于减少动物在发育毒理学中的使用至关重要.
  • 虽然取得了重大进展,但体内研究仍然是全面评估生殖毒性的关键.
  • 需要继续进行研究和验证工作,以提高替代试验的可靠性和监管接受度.