关于选择动物模型进行原性测试的发展特征
Sofia Alves-Pimenta1,2, Bruno Colaço1,2, Paula A Oliveira2,3,4,5
1Department of Animal Science, School of Agrarian and Veterinary Sciences (CECAV), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal.
Methods in molecular biology (Clifton, N.J.)
|January 29, 2024
概括
动物模型对于致病性测试至关重要,无脊椎动物和非哺乳动物脊椎动物提供高效,道德的查. 了解发育途径可以优化化合物安全性和市场速度.
科学领域:
- 发展性毒理学 发展性毒理学
- 比較胚胎學 比較胚胎學
- 动物模型系统动物模型系统
背景情况:
- 动物模型对于新物质的产性测试至关重要.
- 动物的类似发育过程有助于对人类的安全性评估.
- 胚胎学的进步突出了在发育过程中对毒性的敏感性.
研究的目的:
- 在各种动物模型中概述必要的发育时期,以便进行原性测试.
- 比较物种的相似之处,差异,优点和缺点.
- 突出不同模型中对原性测试的特定灵敏度.
主要方法:
- 将动物模型分为无脊椎动物,非哺乳动物脊椎动物和哺乳动物物种.
- 在每个类别中详细说明具体的例子 (例如,Eisenia fetida,Xenopus laevis,Mus musculus).
- 讨论监管要求和越来越多地使用替代模型.
主要成果:
- 无脊椎动物 (例如,Eisenia fetida,C. elegans,D. melanogaster) 提供快速的结果和更少的伦理问题.
- 非哺乳动物的脊椎动物 (例如,Xenopus laevis,Danio rerio) 以较低的道德要求来评估后期的发展.
- 哺乳动物 (例如,Mus musculus,Rattus norvegicus) 对复杂的晚期发育至关重要,但面临查的伦理和成本限制.
结论:
- 无脊椎动物和非哺乳动物的脊椎动物模型是有价值的高通量查,由于成本效益和道德优势.
- 对发育途径的更好理解提高了人类的翻译能力,并减少了对动物的使用.
- 优化动物模型选择可以提高化合物安全性,加速进入市场.
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