清晨与晚上拉塔诺普罗斯特/蒂莫洛尔固定组合在开放角度视光眼和眼睛高血压的有效性:一项随机临床试验
Hui Feng1, Dong Han2, Wensheng Lu2
1Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology & Visual Science Key Lab, Capital Medical University, Beijing, China.
Translational vision science & technology
|January 29, 2024
概括
拉坦诺普罗斯特/蒂莫洛尔固定的组合 (LTFC) 的早晨剂量在控制白内障患者的昼间眼内压力 (IOP) 波动方面更有效. 无论是早上还是晚上,LTFC都有效地降低了24小时内血压和内血压波动.
科学领域:
- 眼科医生 眼科 眼科
- 临床试验 临床试验
- 视光眼管理 视光眼管理
背景情况:
- 主要开角青光眼 (POAG) 和眼睛高血压的特征是眼内压力升高 (IOP).
- 拉塔诺普罗斯特/蒂莫洛尔固定组合 (LTFC) 是一种常见的治疗方法,用于降低IOP.
研究的目的:
- 为了比较早晨和晚上服用拉坦诺普罗斯特/蒂莫洛尔固定组合 (LTFC) 的疗效.
- 评估对POAG和眼睛高血压患者24小时内眼压 (IOP) 和IOP波动的影响.
主要方法:
- 一个双盲随机临床试验,涉及63名未经治疗的中国患者,患有POAG和眼睛高血压.
- 患者随机分配在早上 (8点) 或晚上 (8点) 接受LTFC,持续4周.
- 测量结果包括24小时内血压的平均减少和与基线相比的内血压波动.
主要成果:
- 与基线相比,早上和晚上LTFC显著降低了24小时内血压和内血压波动.
- 早晨剂量显示,与晚上剂量 (0.50 mm Hg;P = 0.012) 相比,白天内血压波动 (2.04 mm Hg) 的减少显著更大.
- 在上午9:30观察到IOP降低的显著差异,偏好晚上剂量 (4.01毫米升) 超过早上剂量 (2.42毫米升;P = 0.048).
结论:
- 无论是在早上还是晚上服用LTFC,都能有效地降低24小时内血压和内血压波动.
- 早晨的LTFC剂量在控制白天内血压波动方面似乎更有效.
- 这项研究提供了在临床实践中优化LTFC剂量方案的证据.
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