在现实的条件下,在各种呼吸活动期间,在健康人群中量化呼出的颗粒
Katharina Schwarz1, Nadja Struß1, Liudmila Banari1
1Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany.
Journal of aerosol medicine and pulmonary drug delivery
|January 29, 2024
概括
呼出的气溶颗粒大小和体积流量在呼吸活动和个体之间有很大差异. 这种关于整个滴滴谱的定量数据对于准确的感染风险评估至关重要.
科学领域:
- 气溶科学是一门气溶科学.
- 传染病流行病学 传染病流行病学
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 准确评估感染风险需要对呼出的气溶的定量数据.
- 之前的研究往往忽略了液滴大小的全部范围.
- 了解气溶排放中的个人间的变异性至关重要.
研究的目的:
- 在各种呼吸活动中量化表征出口气溶的颗粒数和大小分布.
- 为了评估气溶排放的个体间变异性.
- 以简化远场模型为基础进行感染风险评估.
主要方法:
- 健康的参与者进行了标准化的呼吸活动.
- 呼出的气溶采集使用一个带有HEPA过空气的气密头盔.
- 粒子计数器分析了小和大滴滴大小; 应用了质量平衡模型.
主要成果:
- 基于数值的分布主要为<5μm.
- 基于体积的分布有所不同:潮呼吸时2-12微米,其他活动时>60微米.
- 气溶体积流量在各种活动中差异高达100倍,个人间差异很大.
结论:
- 对整个呼出的气溶光谱的定量分析显示了显著的差异.
- 在气溶排放中,个体间的差异很大.
- 这些数据支持改进的感染研究和风险评估模型.
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