机械通风成年人的氧和目标和认知和功能结果
Matthew F Mart1,2,3, Matthew W Semler1, Cathy A Jenkins4
1Division of Allergy, Pulmonary, and Critical Care Medicine.
较低,中等和较高的氧和目标没有影响机械通风成年人的长期认知结果. 这项研究发现,两组人之间在认知能力,残疾或生活质量方面没有显著差异.
科学领域:
- 关键护理医学 关键护理医学
- 神经科学是一个神经科学.
- 肺部病理学 肺部病理学
背景情况:
- 最佳氧气和目标的实用性调查 (PILOT) 试验之前发现,在不同氧气和目标之间,无呼吸器日数没有差异.
- 在机械通风的成年人中,在不同的氧和目标之后,长期的认知和功能结果在很大程度上是未知的.
研究的目的:
- 评估较低 (90%),中等 (94%) 和较高 (98%) 氧气和目标对严重疾病成年人的长期认知和相关结果的影响.
- 在注册后12个月评估全球认知,执行功能,注意力,记忆,口语流和抽象的差异.
主要方法:
- 来自PILOT试验的501名患者的12个月后续评估.
- 盲目的神经心理评分人员进行认知测试,包括电话蒙特利尔认知评估 (T-MoCA) 作为主要结果测量.
- 在一小部分患者中使用了扩展的神经心理电池和残疾,就业和生活质量评估.
主要成果:
- 在较低,中等和较高氧和目标组之间没有观察到T-MoCA得分的显著差异.
- 个人认知领域,残疾状况,就业率和生活质量也在氧气目标群体之间没有显著差异.
- 在相应的较低,中等和较高目标群体中,获得的外周氧和值的中位数为94%,95%和97%.
结论:
- 90%,94%和98%的氧和目标与机械通风重症成人12个月后的长期认知功能或相关结果的差异无关.
- 这些发现表明,当前这种人群的氧气管理策略不会对长期认知健康产生不利影响.
- 进一步的研究可能会探索其他潜在的长期后果或特定的患者亚组.
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