探索人类感应受体多态性R990G适应性表现物的探索
Barbara Sinigaglia1, Jorge Escudero1, Simone A Biagini1
1Institut de Biologia Evolutiva (UPF-CSIC), Departament de Medicina i Ciències de la Vida, Universitat Pompeu Fabra, Parc de Recerca Biomèdica de Barcelona, Barcelona 08003, Spain.
Molecular biology and evolution
|January 29, 2024
概括
东南亚雨林狩猎采集者具有DSWS表型,在感受受体基因周围表现出适应性自然选择. 该基因的一个特定变异 (R990G) 可能促进脂肪积累,有助于在营养压力期间的生存.
科学领域:
- 人类进化遗传学人类进化遗传学
- 生理适应生理适应.
- 信号传递的.
背景情况:
- 东南亚热带雨林的狩猎采集者表现出独特的特征 (DSWS表型):黑色皮肤,矮身,毛发发,和steatopygia.
- 感应受体基因 (CaSR) 对于平衡至关重要,并且已涉及到各种生物功能.
- 之前的研究确定了CaSR中的R990G替代 (rs1042636) 作为DSWS表型人群中潜在的适应变异.
研究的目的:
- 调查R990G CaSR变种在东南亚雨林狩猎采集者的适应意义.
- 探索R990G替代对水平,体重和脂肪积累的生理影响.
主要方法:
- 对相关人类群体中CaSR基因周围的自然选择特征的分析.
- 一个带有R990G CaSR替代物的敲入鼠标模型的生成.
- 敲进小鼠的表型特征,包括血清水平,体重和脂肪成分.
主要成果:
- 在东南亚热带雨林群体中,R990G替代被确定为假定适应变异.
- 同卵同胞的实验小鼠表现出较低的血清度.
- 这些小鼠还显示体重增加和脂肪积累增加,与CaSR激活导致的增强的前脂肪细胞分化和受损的脂解有关.
结论:
- 通过影响新陈代谢和脂肪储存,R990G CaSR变种可能会赋予适应性优势.
- 这些代谢变化可能提高了雨林狩猎采集群体面临营养挑战的生存率.
- 该研究强调了CaSR在人类适应特定环境条件中的作用.
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