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桑马克桑是一种传统的多草药配方,含有帕纳克斯人参,可以改善运动期间的能量代谢
Suji Baek1, Jisu Kim2,3, Myung Hee Nam4
1Research & Development Center, UMUST R&D Corporation, Seoul, Korea.
桑格麦克桑 (SMS) 是Panax人参,Liriope muscari和Schisandra chinensis的混合物,可以增强能量代谢和身体活动. 这项研究通过显示它调节葡萄糖吸收和氧化应激来验证SMS的好处,这表明它是代谢表现的补充剂.
科学领域:
- 草药是一种草药.
- 代谢科学 代谢科学
- 分子生物学分子生物学
背景情况:
- 桑马克桑 (Saengmaeksan,简称SMS) 是一种东方药,传统上用于增强活力和体力活动.
- 有有限的科学证据支持SMS在能量代谢上的所谓好处.
- 了解SMS效应背后的分子机制对于验证其治疗潜力至关重要.
研究的目的:
- 研究SMS及其成分对能量代谢的体外和体内影响.
- 通过SMS阐明了通过SMS调节能量代谢的潜在分子机制.
- 评估SMS作为改善代谢表现的补充剂的潜力.
主要方法:
- 定量实时PCR,3D全息显微镜,3D全息显微镜,3D全息显微镜,3D全息显微镜3D全息显微镜3D全息显微镜3D全息显微镜3D全息显微镜3D全息显微镜3D全息显微镜3D全息显微镜3D全息显微镜3D全息显微镜3D全息显微镜3D全息显微镜3D全息显微镜3D全息显微镜3D全息显微镜3D全息显微镜3D全息显微镜.
- 在小鼠体内使用18F-FCH和18F-FDG PET/CT,免疫组织化学和运动后呼吸气体分析的实验.
- 在接受高强度运动的老鼠的骨肌肉中分析葡萄糖和脂质代谢.
主要成果:
- 短信治疗逆转了L6细胞的葡萄糖吸收,并减少了脂质滴滴体积,类似于单独的Panax人参.
- 在氧化应激条件下SMS调节的细胞外信号调节激酶 (ERK) 和p38酸化,线粒体形态和APE/Ref-1表达.
- 通过SMS调节全身和肌肉能量代谢,包括运动小鼠骨肌中的葡萄糖和脂质代谢.
结论:
- 短信改善了能量代谢失衡,可能通过调节氧化应激诱导的APE/Ref-1表达.
- 这些发现支持SMS作为增强代谢表现的有希望的补充选择.
- 通过其草药成分,SMS显示出对细胞和全身能量代谢的显著调节作用.
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