成年神经肌肉胆瘤,一种罕见的外周神经病理:一个说明性的案例
Ashley Ricciardelli1, Alex Flores1, Hsiang-Chih Lu2
1Departments of1Neurosurgery.
Journal of neurosurgery. Case lessons
|January 29, 2024
概括
神经肌肉胆固醇瘤 (NMCs) 是一种罕见的神经瘤. 这项研究描述了成年人坐骨神经NMC的特征,并指出与儿科病例的相似之处和潜在的侵略性转变.
科学领域:
- 神经病理学神经病理学
- 在瘤学瘤学.
- 周围神经疾病 周围神经疾病
背景情况:
- 神经肌肉胆固醇瘤 (NMCs) 是一种罕见的瘤,在外周神经 (主要是坐骨神经) 中具有异常肌肉纤维.
- NMCs携带的风险是进展到desmoid类型纤维化 (NMC-DTFs),侵略性病变,可能需要截肢.
- 现有的关于成人NMC及其进展到NMC-DTF的文献很少,大多数病例报告在儿科患者中.
研究的目的:
- 在成年人群中表征坐骨神经神经肌肉胆固醇瘤 (NMCs).
- 调查NMCs和NMCs与成人的desmoid型纤维化 (NMC-DTFs) 的发展之间的联系.
- 提供成人NMC病例的全面审查,解决有限的当前信息.
主要方法:
- 一个案例研究的介绍,涉及一个66岁的男性,患有坐骨神经NMC.
- 执行系统文献审查,遵守系统审查和元分析 (PRISMA) 准则的首选报告项目.
- 脊椎神经带神经活检的组织病理学检查,以确定病变.
主要成果:
- 成年男性患者在10年的病史中呈现出渐进的左下肢虚弱和麻醉.
- 磁共振成像显示,近道坐骨神经略增大.
- 文献审查表明,成人NMC病例与儿科NMC有共同的特征.
结论:
- 由于对疾病进展,诊断和治疗的数据有限,对成人NMC的进一步广泛研究至关重要.
- 成人NMC需要谨慎管理,因为手术后转化为NMC-DTF的风险较高.
- 成人NMC与儿科NMC有相似之处,这表明有一个共同的潜在病理生理学.
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