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线粒体向生物仿真平台用于抗骨髓瘤的化疗/光动力学联合治疗

Fengtian Zhang¹, Jiaoting Chen², Weihong Luo³

¹Department of Orthopaedics, Second Affiliated Hospital of Soochow University Osteoporosis Research Institute of Soochow University, 1055 Sanxiang Road, Suzhou 215000, People's Republic of China; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Gannan Medical University, University Park in Rongjiang New District, Ganzhou 341000, People's Republic of China; Department of Orthopedics, First Affiliated Hospital of Gannan Medical University, Jinling East Avenue, Zhanggong District, Ganzhou 341000, People's Republic of China.

International journal of pharmaceutics

|January 29, 2024

概括

一个新的纳米平台,D@SLNP@OSM-IR780,有效地准骨髓瘤 (OS) 细胞和线粒体. 这种联合化学光动力学疗法实现了显著的瘤抑制,并激活了亡,以改善OS治疗.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

骨髓瘤 (OS) 治疗仍然具有挑战性,因为化学疗法的局限性,如严重的副作用和耐药性.
光动力疗法 (PDT) 为癌症治疗提供了一种非侵入性方法,其与化疗的结合显示出增强的疗效.
向线粒体的药物输送是诱导癌细胞亡的关键策略.

研究的目的:

设计和评估一个核心生物模拟纳米平台 (D@SLNP@OSM-IR780) 用于骨髓瘤的向化疗和PDT.
通过纳米平台调解联合化疗-PDT的协同治疗效果的研究.
探索作用机制,包括线粒体向,亡诱导和潜在的光热效应.

主要方法:

开发一个核心结构生物模拟纳米平台 (D@SLNP@OSM-IR780) 用于同类瘤向和线粒体特异性药物释放.
在808nm激光照射后体外评价光细胞毒性.
在体内研究以评估瘤向效率和治疗疗效,包括瘤抑制率.
对协同化学光动力学效应及其对线粒体介导的亡途径和宿主免疫反应的影响的分析.

主要成果:

D@SLNP@OSM-IR780在体外显示出优异的光细胞毒性.
纳米平台在体内表现出显著的瘤向,达到98.9%的瘤抑制率.
证实了协同化学-PDT效应,激活线粒体介导的亡,并可能诱导光热效应和宿主免疫反应.

结论:

D@SLNP@OSM-IR780纳米平台是针对骨髓瘤的向组合治疗的一个有前途的策略.
这种方法有效地克服了单一疗法的局限性,将化疗和PDT与增强的瘤向和线粒体特异性药物输送相结合.
开发的平台有可能通过协同治疗效应来推进骨髓瘤治疗.

关键词:

生物模拟学是一种生物模拟学.化学光动力学疗法化学光动力学疗法针对的线粒体是针对的线粒体.骨质肉瘤骨质肉瘤是什么

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