通过超高性能液体染色学-并联质谱法量化水溶液中的奇托的一种新方法
Ting Xue1, Lei Zhou1, Fanjun Wang1
1Beijing Institute of Radiation Medicine, Beijing 100850, China.
Carbohydrate polymers
|January 29, 2024
概括
这项研究引入了一种新的超高性能液体染色学-并联质谱法 (UPLC-MS/MS) 方法,用于准确量化溶液中的酸盐 (CS). 经过验证的方法可以在各种应用中可靠和实用地确定CS含量.
科学领域:
- 分析化学 分析化学
- 聚合物科学 聚合物科学
背景情况:
- 准确量化素 (CS) 对于其多样化的应用至关重要.
- 现有的CS测定方法可能缺乏特异性或需要复杂的样本准备.
研究的目的:
- 开发和验证一种新,准确和直接的定量分析方法,用于水溶液中的奇多 (CS).
- 使用UPLC-MS/MS建立可靠的CS量化方法.
主要方法:
- 采用超高性能液态染色学-双重质谱法 (UPLC-MS/MS) 进行直接的CS测定.
- 通过将样本度与特征性CS离子对的总离子电流 (TIC) 反应强度线性地匹配,建立了一个标准曲线.
- 在125-4000 ng/mL的度范围内量化CS.
主要成果:
- 在没有干扰峰值的情况下实现了高特异性.
- 证明了出色的线性 (r2 > 0.999),精度 (RSDr < 3%,RSR < 6%),精度 (RE ± 5%) 和稳定性 (RE ± 5%,RSDR < 3%).
- 验证了方法在各种基板和不同复合材料中的适用性.
结论:
- 开发的UPLC-MS/MS方法提供了一个非常准确,具体和可靠的方法来量化.
- 这种方法具有重要的实用价值和经济效益,用于确定不同矩阵中的CS内容.
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