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在ICU患者中实现梅罗的药理动力学/药理动力学目标和临床反应:一项前性观察性研究

Elin Helset¹, Vesa Cheng^2,3, Hilde Sporsem⁴

¹Division of Emergencies and Critical care, Oslo University Hospital, Oslo, Norway.

Acta anaesthesiologica Scandinavica

|January 29, 2024

概括

在大多数重症监护病房患者中,间歇性美罗胺输液实现了目标的实现,但在脏清除增加的患者中没有达到目标. 临床反应各不相同,与美罗的药理动力学/药理动力学目标没有明确的联系.

科学领域:

药理学药理学是指药理学的学科.
关键护理医学关键护理医学
传染性疾病传染性疾病

背景情况:

在重症监护室 (ICU) 患者中,梅罗胺间歇性玻璃注射可能无法达到药理动力学/药理动力学 (PK/PD) 目标.
这可能导致危急病患者治疗失败的风险.

研究的目的:

评估ICU患者在不同功能方面达到美罗的目标 (TA).
为了评估梅罗胺治疗开始后72小时内临床反应.

主要方法:

2014-2017年87名ICU患者 (≥18岁) 的前性观察研究.
包括正常清除 (NRC),增强清除 (ARC) 和持续替代疗法 (CRRT) 的患者.
梅罗因作为1g q6h间歇性玻尿酸输液;通过药物水平和建模评估PK/PD目标. 使用CRP,SOFA评分,白细胞计数和分发光度评估的临床反应.

主要成果:

在NRC和CRRT组中,中位数TA为100%,但在ARC组中只有45.5%.
在总人口中观察到C-反应蛋白 (CRP) 的显著减少 (p < .001).
序列性器官衰竭评估 (SOFA) 得分仅在非CRRT组中得到改善 (p < .001).

结论:

在大多数ICU患者中,间歇性梅罗胺玻尿酸输注可以达到令人满意的目标,除了ARC患者.
在达到美罗胺目标和临床结果之间没有发现一致的相关性.

关键词:

增加了干净度的增加.持续的置换疗法治疗.感染控制的方法更多的是openemenem.人口药物动力学建模的人口药物动力学建模目标的实现目标的实现

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