Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Anti-PD-1 monoclonal antibody suppresses hepatitis B virus in patients with hepatocellular carcinoma.

Chinese medical journal·2026
Same author

Activatable Immunotheranostic Nanovesicles for Coordinated Phagocytic Reprogramming and Real-Time Immune Monitoring.

Journal of the American Chemical Society·2026
Same author

Fat-muscle balance and incident diabetes: evidence from Chinese and UK cohorts.

Diabetes research and clinical practice·2026
Same author

CILP2 exacerbates diabetes-induced muscle atrophy by over-activating skeletal muscle autophagy and inflammation via the P38 MAPK pathway.

International immunopharmacology·2026
Same author

Short-Term Combined Treatment With Tirzepatide and Metformin for Overweight/Obese Chinese Women With Polycystic Ovary Syndrome: A Prospective, Open-Label, Randomised Controlled Trial.

Diabetes, obesity & metabolism·2026
Same author

In-Situ Self-Assembling Multifunctional Peptide-Hydrogel Enables Efficient Bladder Cancer Therapy via Sustained Release of Bacillus Calmette-Guérin and Enhanced Immune Response.

ACS applied materials & interfaces·2026

相关实验视频

Updated: Jul 4, 2025

Author Spotlight: Advancements in Hypoxia-Sensitive CAR-T Therapy for Enhanced Cancer Immunotherapy
09:12

Author Spotlight: Advancements in Hypoxia-Sensitive CAR-T Therapy for Enhanced Cancer Immunotherapy

Published on: June 14, 2024

913

对低氧反应的AIEgens用于精确的疾病预测.

Dongfang Liu1,2, Mengyun Liang3, Aohua Fan1,2

  • 1Key Laboratory of Bionic Engineering, Ministry of Education, Jilin University, Changchun, China.

Luminescence : the journal of biological and chemical luminescence
|January 29, 2024
PubMed
概括
此摘要是机器生成的。

低氧反应的聚合诱导排放光原体 (AIEgens) 提供了精确的疾病诊断和治疗. 这些探测器检测到低氧条件,提高了针对癌症和缺血等疾病的精准医学.

关键词:
聚合引发的排放量 聚合引发的排放量缺氧 缺氧是指缺氧的情况.接近红外线的近红外线光动力学疗法是一种光动力学疗法.他们是天文学家.

更多相关视频

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance
07:07

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance

Published on: February 14, 2025

2.6K
Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
09:17

Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions

Published on: August 2, 2018

18.2K

相关实验视频

Last Updated: Jul 4, 2025

Author Spotlight: Advancements in Hypoxia-Sensitive CAR-T Therapy for Enhanced Cancer Immunotherapy
09:12

Author Spotlight: Advancements in Hypoxia-Sensitive CAR-T Therapy for Enhanced Cancer Immunotherapy

Published on: June 14, 2024

913
Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance
07:07

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance

Published on: February 14, 2025

2.6K
Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
09:17

Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions

Published on: August 2, 2018

18.2K

科学领域:

  • 生物医学工程 生物医学工程
  • 材料科学 材料科学 材料科学
  • 医疗成像医学成像

背景情况:

  • 缺氧,低氧状态,是癌症和缺血等疾病的关键因素.
  • 聚合诱导排放发光剂 (AIEgens) 是具有独特光学特性的先进材料.
  • 生物标志物可激活的探针对于精准医学和神经科学至关重要.

研究的目的:

  • 审查生物医学应用中低氧反应性AIEgens的最新进展.
  • 突出AIEgens在感知和响应低氧微环境中的作用.
  • 讨论这些探针在疾病诊断和治疗中的潜力.

主要方法:

  • 关于对低氧反应的AIE基因及其结构 (例如,亚博,酸,N-氧化物) 的文献综述.
  • 分析AIEgen结构如何响应低氧降解,改变光谱和光特性.
  • 检查图像和治疗瘤和缺血性疾病中的生物应用.

主要成果:

  • 对低氧反应的AIEgens由于减少触发的结构变化而表现出显著的光谱和光变化.
  • 这些探针在癌症和缺血的成像和治疗应用中表现出有效性.
  • 特定的结构图案,如亚博,亚,和N-氧化物是有效的低氧感应.

结论:

  • 对低氧反应的AIEgens代表了神经学和精准医学的重大进步.
  • 这些探针为诊断和治疗缺氧相关疾病提供了更高的精度.
  • 进一步的发展有望改善瘤学和缺血症治疗患者的治疗结果.